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purA protein (Francisella tularensis SCHUS4) - STRING interaction network
"purA" - Adenylosuccinate synthetase in Francisella tularensis SCHUS4
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family (428 aa)    
Predicted Functional Partners:
hpt
Similar to Q8R7L0 Hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcogenesis (181 aa). FASTA- opt- 509 Z-score- 658.7 E()- 8.5e-29 Smith-Waterman score- 509; 47.337 identity in 169 aa overlap (177 aa)
   
 
  0.993
purB
Adenylosuccinate lyase; Similar to PUR8_THEMA Q9X0I0 Adenylosuccinate lyase from Thermotoga maritima (431 aa). FASTA- opt- 1078 Z-score- 1248.5 E()- 1.1e-61 Smith-Waterman score- 1078; 41.628 identity in 430 aa overlap (432 aa)
 
 
  0.990
purH
Similar to PUR9_RHIME (Q92KX6) Bifunctional purine biosynthesis purH from Rhizobium meliloti (536 aa). FASTA- opt- 1834 Z-score- 2200.5 E()- 1.1e-114 Smith-Waterman score- 1834; 55.344identity in 524 aa overlap Includes phosphoribosylaminoimidazolecarboxyamide formyltransferase and IMP synthetase (515 aa)
 
  0.990
guaB
Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family (486 aa)
 
 
  0.987
pyrB
Similar to PYRB_METJA Aspartate carbamoyltransferase from Methanococcus jannaschii (306 aa). FASTA- opt- 943 Z-score- 1081.5 E()- 2.2e-52 Smith-Waterman score- 943; 49.338 identity in 302 aa overlap; Belongs to the ATCase/OTCase family (306 aa)
   
 
  0.951
purCD
Multifunctional fusion protein; Amino acids 1-327 (PurC) similar to AAR06292 SAICAR synthetase from Nicotiana tabacum (399 aa). BLAST- Expect = e-105 Identities = 187/322 (58), Positives = 236/322 (73), Gaps = 6/322 (1). Amino acids 328-770 (PurD) similar to ZP_00077753 Phosphoribosylamine-glycine ligase from Methanosarcina barkeri (433). BLAST- Expect = e-108 Identities = 204/436 (46), Positives = 285/436 (65), Gaps = 3/436 (0); Belongs to the GARS family (770 aa)
   
 
  0.948
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (1290 aa)
   
 
  0.938
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (516 aa)
 
   
  0.937
aspC2
Aminotransferase; Similar to Q83E19 Aspartate aminotransferase from Coxiella burnetii (394 aa). FASTA- opt- 1067 Z-score- 1292.7 E()- 4.1e-64 Smith-Waterman score- 1067; 41.645 identity in 389 aa overlap (397 aa)
 
 
  0.916
ansA
L-asparaginase, type I family protein; Similar to Q8EEG1 L-asparaginase I from Shewanella oneidensis (337 aa). FASTA- opt- 1041 Z-score- 1293.4 E()- 3.7e-64 Smith-Waterman score- 1041; 49.258identity in 337 aa overlap (345 aa)
   
    0.910
Your Current Organism:
Francisella tularensis SCHUS4
NCBI taxonomy Id: 177416
Other names: F. tularensis subsp. tularensis SCHU S4, Francisella tularensis Biovar A str. SCHU S4, Francisella tularensis Biovar A str. Schu 4, Francisella tularensis SCHUS4, Francisella tularensis subsp. tularensis SCHU S4, Francisella tularensis subsp. tularensis Schu 4, Francisella tularensis subsp. tularensis str. SCHU S4, Francisella tularensis subsp. tularensis strain SCHU S4
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