STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvDSimilar to CAD77389 Dihydroxy-acid dehydratase from Rhodopirellula baltica (587 aa). FASTA: opt: 2464 Z-score: 2877.4 E(): 2.2e-152 Smith-Waterman score: 2464; 65.814 identity in 547 aa overlap. 30 aa shorter in the N-terminal than the homologs; Belongs to the IlvD/Edd family. (551 aa)    
Predicted Functional Partners:
leuA
Similar to Q9C5X5 2-isopropylmalate synthase from Arabidopsis thaliana (503 aa). FASTA: opt: 493 Z-score: 601.2 E(): 1.4e-25 Smith-Waterman score: 635; 31.373 identity in 408 aa overlap. This CDS is disrupted by the insertion of an ISFtu1 element occurring very near the C-terminal end. It is not clear whether this insertion affects the function of the protein.
 
 
 0.998
ilvE
Branched-chain amino acid aminotransferase protein (class IV); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.990
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
   
 
 0.928
FTT_0639
Hypothetical protein; Putative fragment. Weak similarity to leuA LE12_METJA (Q58595) 2-isopropylmalate synthase 2 from Methanococcus jannaschii (518 aa). FASTA: opt: 86 Z-score: 142.0 E(): 5.1 Smith-Waterman score: 86; 50.000 identity in 32 aa overlap (1-32:479-510). Next upstream ORF also have similarity to leuA. ORF ftt0639.
  
  
 0.908
ilvH
Similar to Q8A609 Acetolactate synthase large subunit from Bacteroides thetaiotaomicron (565 aa). FASTA: opt: 1850 Z-score: 2038.0 E(): 1.1e-105 Smith-Waterman score: 1850; 50.089 identity in 559 aa overlap. Contains a frameshift after aa 427.
 
 
 0.893
pabB
Chorismate binding family protein; Similar to Q8ESD8 Para-aminobenzoate synthase component II (585 aa) fasta scores; opt: 1108 Z-score: 1235.5 E(): 5.7e-61 Smith-Waterman score: 1108; 33.851 identity in 579 aa overlap. ORF ftt0945.
  
 
 0.809
efp
Elongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation; Belongs to the elongation factor P family.
 
 
  
 0.751
thrC2
Threonine synthase, pseudogene; Similar to THRC_METJA (Q58860) Probable threonine synthase (405 aa). FASTA: opt: opt: 987 Z-score: 1131.2 E(): 3.7e-55 Smith-Waterman score: 987; 44.875 identity in 361 aa overlap. Contains 2 frameshifts after aa 121 and 247.
  
  
 0.689
pheA
Similar to Q83AT4 Amino acid permease family protein from Coxiella burnetii (542 aa). FASTA: opt: 1289 Z-score: 1363.6 E(): 4.6e-68 Smith-Waterman score: 1289; 42.534 identity in 442 aa overlap. Contains an in-frame stop codon after aa 284 and a frameshift after aa 445 ORF ftt0574.
 
  
 0.631
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
 
  
 0.616
Your Current Organism:
Francisella tularensis SCHUS4
NCBI taxonomy Id: 177416
Other names: F. tularensis subsp. tularensis SCHU S4, Francisella tularensis Biovar A str. SCHU S4, Francisella tularensis Biovar A str. Schu 4, Francisella tularensis subsp. tularensis SCHU S4, Francisella tularensis subsp. tularensis Schu 4, Francisella tularensis subsp. tularensis str. SCHU S4, Francisella tularensis subsp. tularensis strain SCHU S4
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