node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FTT_1220 | folD | FTT_1220 | FTT_0892 | 5-formyltetrahydroformate cycloligase family protein; Similar to Q8ZM70 Putative ligase from Salmonella typhimurium (182 aa). FASTA: opt: 317 Z-score: 411.1 E(): 5.2e-15 Smith-Waterman score: 317; 32.727 identity in 165 aa overlap. ORF ftt1220; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.932 |
FTT_1220 | glyA | FTT_1220 | FTT_1241 | 5-formyltetrahydroformate cycloligase family protein; Similar to Q8ZM70 Putative ligase from Salmonella typhimurium (182 aa). FASTA: opt: 317 Z-score: 411.1 E(): 5.2e-15 Smith-Waterman score: 317; 32.727 identity in 165 aa overlap. ORF ftt1220; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.430 |
FTT_1220 | purN | FTT_1220 | FTT_0895 | 5-formyltetrahydroformate cycloligase family protein; Similar to Q8ZM70 Putative ligase from Salmonella typhimurium (182 aa). FASTA: opt: 317 Z-score: 411.1 E(): 5.2e-15 Smith-Waterman score: 317; 32.727 identity in 165 aa overlap. ORF ftt1220; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.937 |
FTT_1220 | purT | FTT_1220 | FTT_1767c | 5-formyltetrahydroformate cycloligase family protein; Similar to Q8ZM70 Putative ligase from Salmonella typhimurium (182 aa). FASTA: opt: 317 Z-score: 411.1 E(): 5.2e-15 Smith-Waterman score: 317; 32.727 identity in 165 aa overlap. ORF ftt1220; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.904 |
fmt | folD | FTT_0925 | FTT_0892 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.962 |
fmt | gcvT | FTT_0925 | FTT_0407 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine cleavage complex protein T (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | 0.911 |
fmt | glyA | FTT_0925 | FTT_1241 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
fmt | purCD | FTT_0925 | FTT_0894 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Fusion protein PurC/PurD; Amino acids 1-327 (PurC) similar to AAR06292 SAICAR synthetase from Nicotiana tabacum (399 aa). BLAST: Expect = e-105 Identities = 187/322 (58), Positives = 236/322 (73), Gaps = 6/322 (1). Amino acids 328-770 (PurD) similar to ZP_00077753 Phosphoribosylamine-glycine ligase from Methanosarcina barkeri (433). BLAST: Expect = e-108 Identities = 204/436 (46), Positives = 285/436 (65), Gaps = 3/436 (0); Belongs to the GARS family. | 0.410 |
fmt | purL | FTT_0925 | FTT_1720c | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Modification methylase, pseudogene; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.451 |
fmt | purN | FTT_0925 | FTT_0895 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.911 |
fmt | purT | FTT_0925 | FTT_1767c | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
folD | FTT_1220 | FTT_0892 | FTT_1220 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 5-formyltetrahydroformate cycloligase family protein; Similar to Q8ZM70 Putative ligase from Salmonella typhimurium (182 aa). FASTA: opt: 317 Z-score: 411.1 E(): 5.2e-15 Smith-Waterman score: 317; 32.727 identity in 165 aa overlap. ORF ftt1220; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.932 |
folD | fmt | FTT_0892 | FTT_0925 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.962 |
folD | gcvT | FTT_0892 | FTT_0407 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage complex protein T (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | 0.955 |
folD | glyA | FTT_0892 | FTT_1241 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.981 |
folD | purCD | FTT_0892 | FTT_0894 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Fusion protein PurC/PurD; Amino acids 1-327 (PurC) similar to AAR06292 SAICAR synthetase from Nicotiana tabacum (399 aa). BLAST: Expect = e-105 Identities = 187/322 (58), Positives = 236/322 (73), Gaps = 6/322 (1). Amino acids 328-770 (PurD) similar to ZP_00077753 Phosphoribosylamine-glycine ligase from Methanosarcina barkeri (433). BLAST: Expect = e-108 Identities = 204/436 (46), Positives = 285/436 (65), Gaps = 3/436 (0); Belongs to the GARS family. | 0.958 |
folD | purH | FTT_0892 | FTT_0203c | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Similar to PUR9_RHIME (Q92KX6) Bifunctional purine biosynthesis purH from Rhizobium meliloti (536 aa). FASTA: opt: 1834 Z-score: 2200.5 E(): 1.1e-114 Smith-Waterman score: 1834; 55.344identity in 524 aa overlap Includes phosphoribosylaminoimidazolecarboxyamide formyltransferase and IMP synthetase. | 0.965 |
folD | purL | FTT_0892 | FTT_1720c | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Modification methylase, pseudogene; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.880 |
folD | purN | FTT_0892 | FTT_0895 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.979 |
folD | purT | FTT_0892 | FTT_1767c | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.901 |