STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ileSIsoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (935 aa)    
Predicted Functional Partners:
pheT
Similar to SYFB_ECOL6 (P59664) Phenylalanyl-tRNA synthetase beta from Escherichia coli (795 aa). FASTA: opt: 2214 Z-score: 2665.4 E(): 1.4e-140 Smith-Waterman score: 2214; 45.125 identity in 800 aa overlap.
  
 
 0.987
proS
Transposase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of [...]
   
 0.983
glnS
Similar to Q87YQ1 Glutaminyl-tRNA synthetase from Pseudomonas syringae (pv. tomato) (569 aa). FASTA: opt: 2160 Z-score: 2562.5 E(): 7.7e-135 Smith-Waterman score: 2160; 57.064 identity in 545 aa overlap.
  
 0.965
metG
tRNA-Ser; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
 0.930
argS
Similar to SYR_SALTY (P74871) Arginyl-tRNA synthetase from Salmonella typhimurium (577 aa). FASTA: opt: 1159 Z-score: 1408.5 E(): 1.5e-70 Smith-Waterman score: 1159; 34.841 identity in 597 aa overlap.
  
 0.923
gltX
Glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
 
 0.918
leuS
Similar to Q83DY1 Leucyl-tRNA synthetase from Coxiella burnetii (820 aa). FASTA: opt: 3351 Z-score: 3699.1 695.4 E(): 3.8e-198 Smith-Waterman score: 3351; 58.952 identity in 821 aa overlap; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
0.917
lspA
Lipoprotein signal peptidase II; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
 
  
 0.912
hisS
Similar to SYH_ECOLI (P04804) Histidyl-tRNA synthetase from E. coli (423 aa). FASTA: opt: 1370 Z-score: 1670.1 E(): 3.9e-85 Smith-Waterman score: 1370; 50.493 identity in 406 aa overlap.
 
  
 0.888
valS
Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
 
 
0.882
Your Current Organism:
Francisella tularensis SCHUS4
NCBI taxonomy Id: 177416
Other names: F. tularensis subsp. tularensis SCHU S4, Francisella tularensis Biovar A str. SCHU S4, Francisella tularensis Biovar A str. Schu 4, Francisella tularensis subsp. tularensis SCHU S4, Francisella tularensis subsp. tularensis Schu 4, Francisella tularensis subsp. tularensis str. SCHU S4, Francisella tularensis subsp. tularensis strain SCHU S4
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