STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metGtRNA-Ser; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (674 aa)    
Predicted Functional Partners:
leuS
Similar to Q83DY1 Leucyl-tRNA synthetase from Coxiella burnetii (820 aa). FASTA: opt: 3351 Z-score: 3699.1 695.4 E(): 3.8e-198 Smith-Waterman score: 3351; 58.952 identity in 821 aa overlap; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 0.996
pheS
Similar to Q883H8 Phenylalanyl-tRNA synthetase, alpha subunit from Pseudomonas syringae (pv. tomato) (338 aa). FASTA: opt: 1579 Z-score: 1874.2 E(): 1.7e-96 Smith-Waterman score: 1579; 64.392 identity in 337 aa overlap.
  
 
 0.990
argS
Similar to SYR_SALTY (P74871) Arginyl-tRNA synthetase from Salmonella typhimurium (577 aa). FASTA: opt: 1159 Z-score: 1408.5 E(): 1.5e-70 Smith-Waterman score: 1159; 34.841 identity in 597 aa overlap.
  
 0.955
glnS
Similar to Q87YQ1 Glutaminyl-tRNA synthetase from Pseudomonas syringae (pv. tomato) (569 aa). FASTA: opt: 2160 Z-score: 2562.5 E(): 7.7e-135 Smith-Waterman score: 2160; 57.064 identity in 545 aa overlap.
  
 0.944
gltX
Glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
  
 0.942
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
 
 0.942
purL
Modification methylase, pseudogene; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
 
  
 0.931
ileS
Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
  
 0.930
pheT
Similar to SYFB_ECOL6 (P59664) Phenylalanyl-tRNA synthetase beta from Escherichia coli (795 aa). FASTA: opt: 2214 Z-score: 2665.4 E(): 1.4e-140 Smith-Waterman score: 2214; 45.125 identity in 800 aa overlap.
  
  
 0.927
proS
Transposase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of [...]
  
 0.910
Your Current Organism:
Francisella tularensis SCHUS4
NCBI taxonomy Id: 177416
Other names: F. tularensis subsp. tularensis SCHU S4, Francisella tularensis Biovar A str. SCHU S4, Francisella tularensis Biovar A str. Schu 4, Francisella tularensis subsp. tularensis SCHU S4, Francisella tularensis subsp. tularensis Schu 4, Francisella tularensis subsp. tularensis str. SCHU S4, Francisella tularensis subsp. tularensis strain SCHU S4
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