STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rncRibonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (230 aa)    
Predicted Functional Partners:
rplS
50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
  
 
 0.969
rplM
50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
   
 
 0.964
rpsI
Similar to RS9_XYLFT (Q87DD4) 30S ribosomal protein S9 from Xylella fastidiosa (strain Temecula1 / ATCC 700964) (130 aa). FASTA: opt: 587 Z-score: 765.1 E(): 1e-34 Smith-Waterman score: 587; 69.600identity in 125 aa overlap; Belongs to the universal ribosomal protein uS9 family.
   
 
 0.961
rpsO
30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
  
 
 0.956
rpsF
30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA.
  
 
 0.956
rpmA
Similar to RL27_YERPE (Q8ZBA7) 50S ribosomal protein L27 from Yersinia pestis (85 aa). FASTA: opt: 431 Z-score: 607.3 E(): 6.2e-26 Smith-Waterman score: 431; 77.108 identity in 83 aa overlap; Belongs to the bacterial ribosomal protein bL27 family.
  
 
 0.955
rplV
50S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
   
 
 0.953
prfB
Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
  
 
 0.952
rplQ
Similar to Q8DS37 50S ribosomal protein L17 from Streptococcus mutans (128 aa). FASTA: opt: 342 Z-score: 447.1 E(): 5.2e-17 Smith-Waterman score: 342; 50.000 identity in 128 aa overlap.
   
 
 0.950
rmpF
Similar to Q9HZN4 50S ribosomal protein L32 from Pseudomonas aeruginosa (59 aa). FASTA: opt: 286 Z-score: 446.7 E(): 4.9e-17 Smith-Waterman score: 286; 71.186 identity in 59 aa overlap; Belongs to the bacterial ribosomal protein bL32 family.
  
   0.948
Your Current Organism:
Francisella tularensis SCHUS4
NCBI taxonomy Id: 177416
Other names: F. tularensis subsp. tularensis SCHU S4, Francisella tularensis Biovar A str. SCHU S4, Francisella tularensis Biovar A str. Schu 4, Francisella tularensis subsp. tularensis SCHU S4, Francisella tularensis subsp. tularensis Schu 4, Francisella tularensis subsp. tularensis str. SCHU S4, Francisella tularensis subsp. tularensis strain SCHU S4
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