STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa)    
Predicted Functional Partners:
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 0.999
trpC
Similar to TRPC_ECOLI (P00909) Tryptophan biosynthesis protein TrpCF from E. coli (452 aa). FASTA: opt: 1577 Z-score: 1915.5 E(): 8.4e-99 Smith-Waterman score: 1577; 55.482 identity in 456 aa overlap Bifunctional protein of tryptophan biosynthesis.
 
 0.999
trpG1
Similarity to Q972A0 Putative anthranilate synthase component from Sulfolobus tokodaii (193 aa). FASTA: opt: 499 Z-score: 620.3 E(): 1.1e-26 Smith-Waterman score: 499; 40.741 identity in 189 aa overlap. Closely related to pabA proteins as they possess a shared domain feature.
 
  
 0.980
trpE
Similar to Q8FHV8 Anthranilate synthase component II from E. coli (531 aa). FASTA: opt: 1761 Z-score: 1951.1 E(): 8e-101 Smith-Waterman score: 1761; 49.808 identity in 522 aa overlap. Contains frameshift after aa 192 unknown EC_number 4.3.1.27.
 
  
 0.944
pabB
Chorismate binding family protein; Similar to Q8ESD8 Para-aminobenzoate synthase component II (585 aa) fasta scores; opt: 1108 Z-score: 1235.5 E(): 5.7e-61 Smith-Waterman score: 1108; 33.851 identity in 579 aa overlap. ORF ftt0945.
 
  
 0.941
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 
 0.929
FTT_0568
Conserved hypothetical membrane protein,pseudogene; Similar to Q83DZ8 Proton/peptide symporter family protein from Coxiella burnetii (504 aa). FASTA: opt: 434 Z-score: 486.3 E(): 3.4e-19 Smith-Waterman score: 434; 22.400identity in 500 aa overlap. Contains 2 frameshifts after aa 102 and 334 ORF ftt0567c.
  
 
 0.909
cbs
Similar to Q8A8A8 Choloylglycine hydrolase from Bacteroides thetaiotaomicron (326 aa). FASTA: opt: 588 Z-score: 716.9 E(): 4.8e-32 Smith-Waterman score: 588; 34.700 identity in 317 aa overlap. Contains an in-frame stop codon at aa 258 ORF ftt1286.
     
 0.906
sdaA
Similar to Q8EEW4 L-serine dehydratase 1 from Shewanella oneidensis (458 aa). FASTA: opt: 1442 Z-score: 1806.4 E(): 1e-92 Smith-Waterman score: 1442; 48.922 identity in 464 aa overlap; Belongs to the iron-sulfur dependent L-serine dehydratase family.
   
 
  0.903
FTT_0835
Similar to Q8EBE8 CDP-diacylglycerol--serine O-phosphatidyltransferase from Shewanella oneidensis (269 aa). FASTA: opt: 456 Z-score: 550.1 E(): 9.5e-23 Smith-Waterman score: 564; 37.209 identity in 258 aa overlap. ORF ftt0835; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
     
  0.900
Your Current Organism:
Francisella tularensis SCHUS4
NCBI taxonomy Id: 177416
Other names: F. tularensis subsp. tularensis SCHU S4, Francisella tularensis Biovar A str. SCHU S4, Francisella tularensis Biovar A str. Schu 4, Francisella tularensis subsp. tularensis SCHU S4, Francisella tularensis subsp. tularensis Schu 4, Francisella tularensis subsp. tularensis str. SCHU S4, Francisella tularensis subsp. tularensis strain SCHU S4
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