node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DP0298 | DP0301 | DP0298 | DP0301 | Probable glycine dehydrogenase, subunit 2. | Related to glycine cleavage system, T protein; Belongs to the GcvT family. | 0.999 |
DP0298 | DP0930 | DP0298 | DP0930 | Probable glycine dehydrogenase, subunit 2. | Probable glutamine synthetase. | 0.842 |
DP0298 | DP1003 | DP0298 | DP1003 | Probable glycine dehydrogenase, subunit 2. | Probable low-specificity L-threonine aldolase. | 0.926 |
DP0298 | DP2491 | DP0298 | DP2491 | Probable glycine dehydrogenase, subunit 2. | Probable delta-1-pyrroline-5-carboxylate dehydrogenase. | 0.809 |
DP0298 | DP2623 | DP0298 | DP2623 | Probable glycine dehydrogenase, subunit 2. | Related to glutamate synthase, alpha subunit. | 0.848 |
DP0298 | gcvH | DP0298 | DP0300 | Probable glycine dehydrogenase, subunit 2. | Probable glycine cleavage system, H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
DP0298 | gcvPA | DP0298 | DP0299 | Probable glycine dehydrogenase, subunit 2. | Probable glycine dehydrogenase, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
DP0298 | glyA | DP0298 | DP1875 | Probable glycine dehydrogenase, subunit 2. | Probable glycine/serine hydroxymethyltransferase (GlyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.983 |
DP0298 | phdd | DP0298 | DP0303 | Probable glycine dehydrogenase, subunit 2. | Related to dihydrolipoamide dehydrogenase, E3 component. | 0.966 |
DP0298 | purE | DP0298 | DP2188 | Probable glycine dehydrogenase, subunit 2. | Probable phosphoribosylamine--glycine ligase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the GARS family. | 0.939 |
DP0301 | DP0298 | DP0301 | DP0298 | Related to glycine cleavage system, T protein; Belongs to the GcvT family. | Probable glycine dehydrogenase, subunit 2. | 0.999 |
DP0301 | DP0930 | DP0301 | DP0930 | Related to glycine cleavage system, T protein; Belongs to the GcvT family. | Probable glutamine synthetase. | 0.842 |
DP0301 | DP2491 | DP0301 | DP2491 | Related to glycine cleavage system, T protein; Belongs to the GcvT family. | Probable delta-1-pyrroline-5-carboxylate dehydrogenase. | 0.836 |
DP0301 | DP2623 | DP0301 | DP2623 | Related to glycine cleavage system, T protein; Belongs to the GcvT family. | Related to glutamate synthase, alpha subunit. | 0.830 |
DP0301 | gcvH | DP0301 | DP0300 | Related to glycine cleavage system, T protein; Belongs to the GcvT family. | Probable glycine cleavage system, H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
DP0301 | gcvPA | DP0301 | DP0299 | Related to glycine cleavage system, T protein; Belongs to the GcvT family. | Probable glycine dehydrogenase, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
DP0301 | glyA | DP0301 | DP1875 | Related to glycine cleavage system, T protein; Belongs to the GcvT family. | Probable glycine/serine hydroxymethyltransferase (GlyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
DP0301 | phdd | DP0301 | DP0303 | Related to glycine cleavage system, T protein; Belongs to the GcvT family. | Related to dihydrolipoamide dehydrogenase, E3 component. | 0.986 |
DP0301 | purE | DP0301 | DP2188 | Related to glycine cleavage system, T protein; Belongs to the GcvT family. | Probable phosphoribosylamine--glycine ligase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the GARS family. | 0.579 |
DP0930 | DP0298 | DP0930 | DP0298 | Probable glutamine synthetase. | Probable glycine dehydrogenase, subunit 2. | 0.842 |