node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DP0005 | DP2888 | DP0005 | DP2888 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | 0.435 |
DP0005 | cobQ | DP0005 | DP1950 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Related to aminotransferase and cobyric acid synthase (CobD and CobQ); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.825 |
DP0005 | hisB | DP0005 | DP1328 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Probable imidazoleglycerol-phosphate dehydratase. | 0.934 |
DP0005 | hisC | DP0005 | DP0642 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Probable histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.910 |
DP0005 | hisD | DP0005 | DP1282 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Probable histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.934 |
DP0005 | hisG | DP0005 | DP2638 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Related to ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.934 |
DP0005 | hisH | DP0005 | DP2167 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Related to bifunctional histidine biosynthesis protein (HisHF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF; Belongs to the HisA/HisF family. | 0.999 |
DP0005 | hisI | DP0005 | DP2639 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Probable phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.993 |
DP0093 | DP2888 | DP0093 | DP2888 | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | 0.967 |
DP0093 | hisC | DP0093 | DP0642 | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Probable histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.909 |
DP0093 | hisD | DP0093 | DP1282 | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Probable histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.939 |
DP0093 | hisH | DP0093 | DP2167 | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Related to bifunctional histidine biosynthesis protein (HisHF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF; Belongs to the HisA/HisF family. | 0.740 |
DP2888 | DP0005 | DP2888 | DP0005 | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | 0.435 |
DP2888 | DP0093 | DP2888 | DP0093 | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | 0.967 |
DP2888 | hisB | DP2888 | DP1328 | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Probable imidazoleglycerol-phosphate dehydratase. | 0.452 |
DP2888 | hisC | DP2888 | DP0642 | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Probable histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.942 |
DP2888 | hisD | DP2888 | DP1282 | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Probable histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.944 |
DP2888 | hisH | DP2888 | DP2167 | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Related to bifunctional histidine biosynthesis protein (HisHF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF; Belongs to the HisA/HisF family. | 0.609 |
DP2888 | hisI | DP2888 | DP2639 | Related to histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Probable phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.467 |
cobQ | DP0005 | DP1950 | DP0005 | Related to aminotransferase and cobyric acid synthase (CobD and CobQ); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | 0.825 |