node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PAE3299 | PAE3300 | PAE3299 | PAE3300 | Acetolactate synthase small subunit; Amino acid biosynthesis; Pyruvate family. | Acetolactate synthase large subunit (ilvB); Amino acid biosynthesis; Pyruvate family. | 0.984 |
PAE3299 | PAE3301 | PAE3299 | PAE3301 | Acetolactate synthase small subunit; Amino acid biosynthesis; Pyruvate family. | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. | 0.545 |
PAE3299 | PAE3303 | PAE3299 | PAE3303 | Acetolactate synthase small subunit; Amino acid biosynthesis; Pyruvate family. | Hypothetical protein. | 0.401 |
PAE3299 | ilvC | PAE3299 | PAE3298 | Acetolactate synthase small subunit; Amino acid biosynthesis; Pyruvate family. | Acetohydroxy acid isomeroreductase (ilvC); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.982 |
PAE3299 | ilvE | PAE3299 | PAE3297 | Acetolactate synthase small subunit; Amino acid biosynthesis; Pyruvate family. | Branched-chain amino acid aminotransferase (ilvE); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.775 |
PAE3300 | PAE3299 | PAE3300 | PAE3299 | Acetolactate synthase large subunit (ilvB); Amino acid biosynthesis; Pyruvate family. | Acetolactate synthase small subunit; Amino acid biosynthesis; Pyruvate family. | 0.984 |
PAE3300 | PAE3301 | PAE3300 | PAE3301 | Acetolactate synthase large subunit (ilvB); Amino acid biosynthesis; Pyruvate family. | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. | 0.717 |
PAE3300 | PAE3303 | PAE3300 | PAE3303 | Acetolactate synthase large subunit (ilvB); Amino acid biosynthesis; Pyruvate family. | Hypothetical protein. | 0.401 |
PAE3300 | ilvC | PAE3300 | PAE3298 | Acetolactate synthase large subunit (ilvB); Amino acid biosynthesis; Pyruvate family. | Acetohydroxy acid isomeroreductase (ilvC); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
PAE3300 | ilvE | PAE3300 | PAE3297 | Acetolactate synthase large subunit (ilvB); Amino acid biosynthesis; Pyruvate family. | Branched-chain amino acid aminotransferase (ilvE); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.979 |
PAE3301 | PAE3299 | PAE3301 | PAE3299 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. | Acetolactate synthase small subunit; Amino acid biosynthesis; Pyruvate family. | 0.545 |
PAE3301 | PAE3300 | PAE3301 | PAE3300 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. | Acetolactate synthase large subunit (ilvB); Amino acid biosynthesis; Pyruvate family. | 0.717 |
PAE3301 | PAE3303 | PAE3301 | PAE3303 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. | Hypothetical protein. | 0.574 |
PAE3301 | csl4 | PAE3301 | PAE1975 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. | Conserved protein (RNA polymerase related); Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. | 0.599 |
PAE3301 | flpA | PAE3301 | PAE3228 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. | Fibrillarin-like pre-rRNA processing protein (flpA); Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. | 0.818 |
PAE3301 | ilvC | PAE3301 | PAE3298 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. | Acetohydroxy acid isomeroreductase (ilvC); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.597 |
PAE3301 | ilvE | PAE3301 | PAE3297 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. | Branched-chain amino acid aminotransferase (ilvE); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.566 |
PAE3301 | rrp4 | PAE3301 | PAE2208 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. | Conserved hypothetical protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. | 0.540 |
PAE3301 | rrp41 | PAE3301 | PAE2207 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. | 3' exoribonuclease family protein; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails. | 0.608 |
PAE3301 | rrp42 | PAE3301 | PAE2206 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. | 3' exoribonuclease family protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. | 0.592 |