STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrE_1Orotate phosphoribosyltransferase. (207 aa)    
Predicted Functional Partners:
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
 
 0.985
pyrK
Dihydroorotate oxidase B, electron transfer subunit.
  
 
 0.983
pyrDB
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.
  
 0.979
preA_2
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA; Catalyzes the conversion of dihydroorotate to orotate.
  
 0.979
pyrB
Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
  
 0.960
pyrR
Pyrimidine operon regulatory protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
  
  
 0.953
pyrC_2
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
  
  
 0.931
pyrE_2
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
  
 
0.928
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
 
 
 0.865
carA
Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.
  
  
 0.862
Your Current Organism:
Luteitalea pratensis
NCBI taxonomy Id: 1855912
Other names: Acidobacteria bacterium DSM 100886, Acidobacteria bacterium HEG_-6_39, DSM 100886, KCTC 52215, L. pratensis, Luteitalea pratensis Vieira et al. 2017, strain HEG_-6_39
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