node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF0020 | cdc6 | PF0020 | PF0017 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the UPF0173 family. | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | 0.621 |
PF0020 | polB | PF0020 | PF0018 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the UPF0173 family. | DNA polymerase II subunit 1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. | 0.621 |
PF0020 | polC | PF0020 | PF0019 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the UPF0173 family. | DNA polymerase II subunit 2; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. | 0.621 |
PF0020 | radB | PF0020 | PF0021 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the UPF0173 family. | Recombinase; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. | 0.849 |
PF0670 | radB | PF0670 | PF0021 | RNase l inhibitor; Function Code: 10 Regulatory Functions: REGULATORY FUNCTIONS. | Recombinase; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. | 0.667 |
PF2020 | cdc6 | PF2020 | PF0017 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | 0.698 |
PF2020 | fen | PF2020 | PF1414 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.619 |
PF2020 | pcn | PF2020 | PF0983 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | Pcna sliding clamp (proliferating-cell nuclear antigen); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Unlike its eukaryotic paralog, loads on circular DNA without the replication factor C (RFC) clamp loader, although RFC greatly increases loading efficiency. Stimulates the ATPase activity of replication factor C (RFC) in the presence of ssDNA. Stimulates the helicase activity of Hel308 and may alter its substrate specificity. | 0.941 |
PF2020 | pol | PF2020 | PF0212 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity. | 0.780 |
PF2020 | polB | PF2020 | PF0018 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | DNA polymerase II subunit 1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. | 0.730 |
PF2020 | polC | PF2020 | PF0019 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | DNA polymerase II subunit 2; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. | 0.477 |
PF2020 | radB | PF2020 | PF0021 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | Recombinase; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. | 0.704 |
PF2020 | topA | PF2020 | PF0494 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.908 |
cdc6 | PF0020 | PF0017 | PF0020 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the UPF0173 family. | 0.621 |
cdc6 | PF2020 | PF0017 | PF2020 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | 0.698 |
cdc6 | fen | PF0017 | PF1414 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.730 |
cdc6 | pcn | PF0017 | PF0983 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | Pcna sliding clamp (proliferating-cell nuclear antigen); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Unlike its eukaryotic paralog, loads on circular DNA without the replication factor C (RFC) clamp loader, although RFC greatly increases loading efficiency. Stimulates the ATPase activity of replication factor C (RFC) in the presence of ssDNA. Stimulates the helicase activity of Hel308 and may alter its substrate specificity. | 0.567 |
cdc6 | pol | PF0017 | PF0212 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity. | 0.833 |
cdc6 | polB | PF0017 | PF0018 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | DNA polymerase II subunit 1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. | 0.982 |
cdc6 | polC | PF0017 | PF0019 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | DNA polymerase II subunit 2; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. | 0.966 |