STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wtpCMembrane protein; Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Probably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family. (344 aa)    
Predicted Functional Partners:
wtpB
Sulfate/thiosulfate transport protein homolog cyst; Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Probably responsible for the translocation of the substrate across the membrane.
 0.995
wtpA
Hypothetical protein; Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Binds tungstate and molybdate, with a preference for tungstate.
 
  
  0.968
PF0577
Function Code: 14.1 Transport and Binding Proteins: General.
 
     
0.847
PF1616
Myo-inositol-1-phosphate synthase; Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; (ino1).
      
 0.767
secY
Preprotein translocase; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. Complements an E.coli temp [...]
      
 0.752
PF0733
Putative ABC transporter (ATP-binding protein); Function Code: 14.1 Transport and Binding Proteins: General.
 
    
0.677
PF0263
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the GbsR family.
      
 0.629
PF0649
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the GbsR family.
      
 0.629
mre11
Exonuclease putative; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.
      
 0.624
porB
Pyruvate ferredoxin oxidoreductase subunit beta-2; Function Code: 6.5 Energy Metabolism: Fermentation.
      
 0.613
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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