node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF0482 | PF2020 | PF0482 | PF2020 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | 0.888 |
PF0482 | fen | PF0482 | PF1414 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.930 |
PF0482 | pcn | PF0482 | PF0983 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Pcna sliding clamp (proliferating-cell nuclear antigen); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Unlike its eukaryotic paralog, loads on circular DNA without the replication factor C (RFC) clamp loader, although RFC greatly increases loading efficiency. Stimulates the ATPase activity of replication factor C (RFC) in the presence of ssDNA. Stimulates the helicase activity of Hel308 and may alter its substrate specificity. | 0.951 |
PF0482 | pol | PF0482 | PF0212 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity. | 0.976 |
PF0482 | polB | PF0482 | PF0018 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | DNA polymerase II subunit 1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. | 0.742 |
PF0482 | priL | PF0482 | PF0111 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.980 |
PF0482 | priS | PF0482 | PF0110 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | DNA primase, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May [...] | 0.956 |
PF0482 | rfcL | PF0482 | PF0092 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Replication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. | 0.901 |
PF0482 | rfcS | PF0482 | PF0093 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.946 |
PF0482 | top6B | PF0482 | PF1579 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | DNA topoisomerase VI, subunit b; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. | 0.544 |
PF2020 | PF0482 | PF2020 | PF0482 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | 0.888 |
PF2020 | fen | PF2020 | PF1414 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.619 |
PF2020 | pcn | PF2020 | PF0983 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | Pcna sliding clamp (proliferating-cell nuclear antigen); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Unlike its eukaryotic paralog, loads on circular DNA without the replication factor C (RFC) clamp loader, although RFC greatly increases loading efficiency. Stimulates the ATPase activity of replication factor C (RFC) in the presence of ssDNA. Stimulates the helicase activity of Hel308 and may alter its substrate specificity. | 0.941 |
PF2020 | pol | PF2020 | PF0212 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity. | 0.780 |
PF2020 | polB | PF2020 | PF0018 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | DNA polymerase II subunit 1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. | 0.730 |
PF2020 | priL | PF2020 | PF0111 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | Hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.737 |
PF2020 | priS | PF2020 | PF0110 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | DNA primase, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May [...] | 0.781 |
PF2020 | rfcL | PF2020 | PF0092 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | Replication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. | 0.724 |
PF2020 | rfcS | PF2020 | PF0093 | Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.748 |
fen | PF0482 | PF1414 | PF0482 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | 0.930 |