node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF0482 | cdc6 | PF0482 | PF0017 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | 0.999 |
PF0482 | fen | PF0482 | PF1414 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.930 |
PF0482 | pcn | PF0482 | PF0983 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Pcna sliding clamp (proliferating-cell nuclear antigen); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Unlike its eukaryotic paralog, loads on circular DNA without the replication factor C (RFC) clamp loader, although RFC greatly increases loading efficiency. Stimulates the ATPase activity of replication factor C (RFC) in the presence of ssDNA. Stimulates the helicase activity of Hel308 and may alter its substrate specificity. | 0.951 |
PF0482 | pol | PF0482 | PF0212 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity. | 0.976 |
PF0482 | polB | PF0482 | PF0018 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | DNA polymerase II subunit 1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. | 0.742 |
PF0482 | priL | PF0482 | PF0111 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.980 |
PF0482 | priS | PF0482 | PF0110 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | DNA primase, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May [...] | 0.956 |
PF0482 | rfcL | PF0482 | PF0092 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Replication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. | 0.901 |
PF0482 | rfcS | PF0482 | PF0093 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.946 |
cdc6 | PF0482 | PF0017 | PF0482 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | 0.999 |
cdc6 | dnaG | PF0017 | PF1725 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | Hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.875 |
cdc6 | fen | PF0017 | PF1414 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.730 |
cdc6 | pcn | PF0017 | PF0983 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | Pcna sliding clamp (proliferating-cell nuclear antigen); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Unlike its eukaryotic paralog, loads on circular DNA without the replication factor C (RFC) clamp loader, although RFC greatly increases loading efficiency. Stimulates the ATPase activity of replication factor C (RFC) in the presence of ssDNA. Stimulates the helicase activity of Hel308 and may alter its substrate specificity. | 0.567 |
cdc6 | pol | PF0017 | PF0212 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity. | 0.833 |
cdc6 | polB | PF0017 | PF0018 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | DNA polymerase II subunit 1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. | 0.982 |
cdc6 | priL | PF0017 | PF0111 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | Hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.959 |
cdc6 | priS | PF0017 | PF0110 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | DNA primase, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May [...] | 0.938 |
cdc6 | rfcL | PF0017 | PF0092 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | Replication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. | 0.677 |
cdc6 | rfcS | PF0017 | PF0093 | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.631 |
dnaG | cdc6 | PF1725 | PF0017 | Hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. | 0.875 |