STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spt4DNA-directed RNA polymerase, subunit e'; Stimulates transcription elongation. Belongs to the archaeal Spt4 family. (61 aa)    
Predicted Functional Partners:
spt5
Transcription antitermination protein nusG; Stimulates transcription elongation. Belongs to the archaeal Spt5 family.
  
 
 0.999
PF0256
DNA-directed RNA polymerase, subunit e; Function Code: 12.1 Transcription: DNA-dependent RNA polymerase; (rpoE1).
 
 
 0.996
rps27ae
Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps27AE); Belongs to the eukaryotic ribosomal protein eS31 family.
 
    0.956
PF0254
Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
 
    0.937
rps24e
Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps24E).
  
    0.869
PF1563
DNA-directed RNA polymerase subunit a; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.826
ppa
Inorganic pyrophosphatase (pyrophosphate phospho-hydrolase); Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
       0.767
rpoP
Hypothetical protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.
   
  
 0.684
PF1385
DNA polymerase, bacteriophage-type; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair.
      
 0.636
rps6e
Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps6E).
 
    0.629
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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