STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (483 aa)    
Predicted Functional Partners:
PF2038
Cob(i)alamin adenosyltransferase; Function Code: 2.1 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: General.
  
 0.992
cobD
Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
 
 0.990
PF0293
Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1).
  
 0.956
PF0305
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
 
  
  0.948
hisC
Putative histidinol-phosphate aminotransferase (imidazole; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family.
 
  
 0.927
PF0303
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the UPF0284 family.
 
  
 0.915
cobS
Cobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
  
 0.801
PF0302
Co-factor modifying protein; Function Code: 2.1 Biosynthesis of cofactors, prosthetic groups, and carriers: General.
       0.799
cobS-2
Cobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
  
 0.679
PF0979
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
 
  
 0.530
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.