STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ahcYS-adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (421 aa)    
Predicted Functional Partners:
PF1268
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
  
 
 0.958
metE
Methionine synthase, vitamin-B12 independent isozyme); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown (By similarity).
  
 
 0.958
PF1266
Cystathionine gamma-lyase (gamma-cystathionase); Function Code: 1.6 Amino Acid Biosynthesis: Serine family.
  
 0.954
PF1858
Cysteine synthase; Function Code: 1.6 Amino Acid Biosynthesis: Serine family.
  
 0.918
PF0049
Site-specific DNA-methyltransferase (cytosine-specific); Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 0.914
PF1104
Homoserine dehydrogenase; Function Code: 1.3 Amino Acid Biosynthesis: Aspartate family.
  
 
 0.828
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
    
  0.800
PF1267
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
  
  
 0.693
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.692
PF0345
Molybdopterin converting factor, subunit 1; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin; (moaD).
       0.654
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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