node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF0667 | purC | PF0667 | PF0153 | Adenylosuccinate lyase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (purB); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; Belongs to the SAICAR synthetase family. | 0.999 |
PF0667 | purD | PF0667 | PF0422 | Adenylosuccinate lyase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (purB); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylamine-glycine ligase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (GARS). | 0.993 |
PF0667 | purE | PF0667 | PF0427 | Adenylosuccinate lyase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (purB); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.995 |
PF0667 | purF | PF0667 | PF0154 | Adenylosuccinate lyase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (purB); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.997 |
PF0667 | purK | PF0667 | PF0426 | Adenylosuccinate lyase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (purB); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.996 |
PF0667 | purL | PF0667 | PF0199 | Adenylosuccinate lyase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (purB); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.992 |
PF0667 | purM | PF0667 | PF0431 | Adenylosuccinate lyase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (purB); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine cyclo-ligase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (purM). | 0.989 |
PF0667 | purQ | PF0667 | PF0198 | Adenylosuccinate lyase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (purB); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine synthase (FGAM synthase i); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is tho [...] | 0.977 |
PF0667 | purS | PF0667 | PF0197 | Adenylosuccinate lyase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (purB); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the am [...] | 0.973 |
PF0667 | purT | PF0667 | PF0430 | Adenylosuccinate lyase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (purB); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.699 |
purC | PF0667 | PF0153 | PF0667 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; Belongs to the SAICAR synthetase family. | Adenylosuccinate lyase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (purB); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.999 |
purC | purD | PF0153 | PF0422 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; Belongs to the SAICAR synthetase family. | Phosphoribosylamine-glycine ligase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (GARS). | 0.998 |
purC | purE | PF0153 | PF0427 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; Belongs to the SAICAR synthetase family. | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.999 |
purC | purF | PF0153 | PF0154 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; Belongs to the SAICAR synthetase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.999 |
purC | purK | PF0153 | PF0426 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; Belongs to the SAICAR synthetase family. | Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.999 |
purC | purL | PF0153 | PF0199 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; Belongs to the SAICAR synthetase family. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.997 |
purC | purM | PF0153 | PF0431 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; Belongs to the SAICAR synthetase family. | Phosphoribosylformylglycinamidine cyclo-ligase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; (purM). | 0.997 |
purC | purQ | PF0153 | PF0198 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; Belongs to the SAICAR synthetase family. | Phosphoribosylformylglycinamidine synthase (FGAM synthase i); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is tho [...] | 0.997 |
purC | purS | PF0153 | PF0197 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; Belongs to the SAICAR synthetase family. | Hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the am [...] | 0.996 |
purC | purT | PF0153 | PF0430 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function Code: 9.3 Purines, Pyrimidines, Nucleosides and Nucleotides: Purine ribonucleotide biosynthesis; Belongs to the SAICAR synthetase family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.725 |