STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnrRibonucleotide reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase class-2 family. (1740 aa)    
Predicted Functional Partners:
pcn
Pcna sliding clamp (proliferating-cell nuclear antigen); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Unlike its eukaryotic paralog, loads on circular DNA without the replication factor C (RFC) clamp loader, although RFC greatly increases loading efficiency. Stimulates the ATPase activity of replication factor C (RFC) in the presence of ssDNA. Stimulates the helicase activity of Hel308 and may alter its substrate specificity.
  
 
 0.974
tmk
Thymidylate kinase (tmk); Function Code: 9.2 Purines, Pyrimidines, Nucleosides and Nucleotides: Nucleotide and nucleoside interconversions.
 
 
 0.963
PF0482
Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family.
  
  
 0.957
adk
Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
    
 0.937
ndk
Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    
 0.929
adkA
Adenylate kinase (ATP-AMP transphosphorylase); Function Code: 9.2 Purines, Pyrimidines, Nucleosides and Nucleotides: Nucleotide and nucleoside interconversions; Belongs to the archaeal adenylate kinase family.
  
  
  0.917
PF1188
Pyruvate kinase; Function Code: 6.7 Energy Metabolism: Glycolysis; Belongs to the pyruvate kinase family.
    
 0.912
PF1134
Hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
  
 
  0.904
cmk
Cytidylate kinase (ck) (cytidine monophosphate kinase) (CMP kinase); Function Code: 9.2 Purines, Pyrimidines, Nucleosides and Nucleotides: Nucleotide and nucleoside interconversions.
    
  0.903
PF0501
Gtpase domain, related to era and thdf; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
     
 0.901
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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