STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PF0473O-sialoglycoprotein endopeptidase; Function Code: 13.2 Translation: Degradation of proteins, peptides, and glycopeptides; (gcp-2). (226 aa)    
Predicted Functional Partners:
kae1
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
   
 0.981
PF0523
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
    
 
 0.884
PF2011
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
      
 0.750
PF0825
Prolyl endopeptidase; Function Code: 13.2 Translation: Degradation of proteins, peptides, and glycopeptides.
  
   
 0.668
PF0655
Serine/threonine-protein kinase; Function Code: 16 Unknown:.
  
 
 
 0.619
pcp
Pyroglutamyl-peptidase i; Removes 5-oxoproline from various penultimate amino acid residues except L-proline; Belongs to the peptidase C15 family.
  
  
 0.609
PF0472
Function Code: 16.4 Hypothetical.
       0.567
rps15
Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps15P).
 
   
 0.560
rps24e
Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps24E).
  
    0.512
PF0471
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
       0.483
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.