STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PF0476Competence-damage inducible protein, putative; Function Code: 16 Unknown:; Belongs to the CinA family. (252 aa)    
Predicted Functional Partners:
PF0475
Translation initiation factor eIF-2b, subunit delta; Catalyzes the exchange of initiation factor 2-bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family.
       0.792
mutS2
DNA mismatch repair protein; Has ATPase and non-specific DNA-binding activities. May be involved in recombination and/or recombinational repair. Not involved in mismatch repair; Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
       0.790
PF0462
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  
  
 0.716
PF0940
3-isopropylmalate dehydrogenase 2; Function Code: 1.5 Amino Acid Biosynthesis: Pyruvate family (leuB2); (leuB).
      0.647
PF0477
Alpha-amylase; Function Code: 5.1 Central Intermediary Metabolism: Degradation of polysaccharides.
       0.540
PF0027
Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family.
     
 0.484
gap
Glyceraldehyde-3-phosphate dehydrogenase; Active in the presence of NAD and NADP; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
 
     0.457
ftsY
Signal recognition particle receptor (dpa); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
 
     0.448
PF0129
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
     
 0.420
PF1912
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
  
  
 0.411
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.