STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis. (315 aa)    
Predicted Functional Partners:
argG
Argininosuccinate synthase; Function Code: 1.4 Amino Acid Biosynthesis: Glutamate family; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
 
 
 0.997
PF2044
Glycogen synthase; Function Code: 3.2 Cell Envelope: Surface polysaccharides, lipopolysaccharides and antigens; (starch).
  
  
 0.996
carB
Carbamoyl-phosphate synthase large chain (glutamine-hydrolysing); Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis.
 
 
 0.991
carA
Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family.
 
   
  0.979
lysY
N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
 
  
 0.968
PF1535
Alpha-glucan phosphorylase; Function Code: 5.1 Central Intermediary Metabolism: Degradation of polysaccharides.
  
  
 0.963
lysK
Acetylornithine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
  
 
 0.943
cpkA
Carbamate kinase-like carbamoylphosphate synthetase; Carbamate kinase that plays a biosynthetic role in that it produces carbamoyl-phosphate.
 
  
 0.938
PF1185
Acetylornithine deacetylase; Function Code: 1.4 Amino Acid Biosynthesis: Glutamate family; (argE).
  
 
 0.920
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
  
 0.914
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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