node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF1240 | carA | PF1240 | PF1713 | Putative purine permease; Function Code: 14.6 Transport and Binding Proteins: Other. | Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family. | 0.959 |
PF1240 | carB | PF1240 | PF1714 | Putative purine permease; Function Code: 14.6 Transport and Binding Proteins: Other. | Carbamoyl-phosphate synthase large chain (glutamine-hydrolysing); Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis. | 0.952 |
PF1240 | purA | PF1240 | PF0308 | Putative purine permease; Function Code: 14.6 Transport and Binding Proteins: Other. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.427 |
PF1240 | pyrB | PF1240 | PF0599 | Putative purine permease; Function Code: 14.6 Transport and Binding Proteins: Other. | Aspartate carbamoyltransferase, catalytic subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (pyrB). | 0.996 |
PF1240 | pyrC | PF1240 | PF0189 | Putative purine permease; Function Code: 14.6 Transport and Binding Proteins: Other. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.979 |
PF1240 | pyrD | PF1240 | PF1539 | Putative purine permease; Function Code: 14.6 Transport and Binding Proteins: Other. | Dihydroorotate dehydrogenase (dihydroorotate oxidase) (dhodehase); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.846 |
PF1240 | pyrE | PF1240 | PF1034 | Putative purine permease; Function Code: 14.6 Transport and Binding Proteins: Other. | Orotate phosphoribosyl transferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.951 |
PF1240 | pyrF | PF1240 | PF1114 | Putative purine permease; Function Code: 14.6 Transport and Binding Proteins: Other. | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.958 |
carA | PF1240 | PF1713 | PF1240 | Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family. | Putative purine permease; Function Code: 14.6 Transport and Binding Proteins: Other. | 0.959 |
carA | carB | PF1713 | PF1714 | Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family. | Carbamoyl-phosphate synthase large chain (glutamine-hydrolysing); Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis. | 0.999 |
carA | cpkA | PF1713 | PF0676 | Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family. | Carbamate kinase-like carbamoylphosphate synthetase; Carbamate kinase that plays a biosynthetic role in that it produces carbamoyl-phosphate. | 0.808 |
carA | purA | PF1713 | PF0308 | Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.574 |
carA | pyrB | PF1713 | PF0599 | Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family. | Aspartate carbamoyltransferase, catalytic subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (pyrB). | 0.999 |
carA | pyrC | PF1713 | PF0189 | Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
carA | pyrD | PF1713 | PF1539 | Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family. | Dihydroorotate dehydrogenase (dihydroorotate oxidase) (dhodehase); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.989 |
carA | pyrE | PF1713 | PF1034 | Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family. | Orotate phosphoribosyl transferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.993 |
carA | pyrF | PF1713 | PF1114 | Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family. | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.995 |
carA | pyrI | PF1713 | PF0598 | Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family. | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.969 |
carB | PF1240 | PF1714 | PF1240 | Carbamoyl-phosphate synthase large chain (glutamine-hydrolysing); Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis. | Putative purine permease; Function Code: 14.6 Transport and Binding Proteins: Other. | 0.952 |
carB | carA | PF1714 | PF1713 | Carbamoyl-phosphate synthase large chain (glutamine-hydrolysing); Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis. | Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family. | 0.999 |