STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cpkACarbamate kinase-like carbamoylphosphate synthetase; Carbamate kinase that plays a biosynthetic role in that it produces carbamoyl-phosphate. (314 aa)    
Predicted Functional Partners:
glnA
Glutamine synthetase i; Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
     
 0.952
pyrB
Aspartate carbamoyltransferase, catalytic subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (pyrB).
    
 0.952
gdhA
Glutamate dehydrogenase; Function Code: 5.6 Central Intermediary Metabolism: Other; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
     
 0.943
argF
Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis.
 
  
 0.938
purQ
Phosphoribosylformylglycinamidine synthase (FGAM synthase i); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is tho [...]
    
  0.901
pyrI
Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase.
    
  0.814
carA
Carbamoyl-phosphate synthase, small (or glutamine) subunit; Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis; (carA); Belongs to the CarA family.
     
 0.808
carB
Carbamoyl-phosphate synthase large chain (glutamine-hydrolysing); Function Code: 9.4 Purines, Pyrimidines, Nucleosides and Nucleotides: Pyrimidine ribonucleotide biosynthesis.
     
 0.806
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
     
 0.782
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor.
     
 0.653
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.