node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF0852 | PF0853 | PF0852 | PF0853 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | 5'-methylthioadenosine phosphorylase II; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.508 |
PF0852 | guaAB | PF0852 | PF1516 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.456 |
PF0853 | PF0852 | PF0853 | PF0852 | 5'-methylthioadenosine phosphorylase II; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | 0.508 |
PF0853 | PF0854 | PF0853 | PF0854 | 5'-methylthioadenosine phosphorylase II; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | Function Code: 5.1 Central Intermediary Metabolism: Degradation of polysaccharides. | 0.410 |
PF0853 | PF0855 | PF0853 | PF0855 | 5'-methylthioadenosine phosphorylase II; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | 0.410 |
PF0853 | PF1349 | PF0853 | PF1349 | 5'-methylthioadenosine phosphorylase II; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | Translation initiation factor eIF-2 beta chain; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.926 |
PF0853 | guaAB | PF0853 | PF1516 | 5'-methylthioadenosine phosphorylase II; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.408 |
PF0853 | mtaD | PF0853 | PF1538 | 5'-methylthioadenosine phosphorylase II; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | N-ethylammeline chlorohydrolase; Catalyzes the deamination of 5-methylthioadenosine and S- adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine. Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family. | 0.972 |
PF0853 | mtnP | PF0853 | PF0016 | 5'-methylthioadenosine phosphorylase II; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 5'-methylthioadenosine phosphorylase I; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.907 |
PF0853 | speE | PF0853 | PF0127 | 5'-methylthioadenosine phosphorylase II; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to various amine acceptors such as agmatine, cadaverine (1,5-diaminopentane), putrescine (1,4- diaminobutane) and 1,3-diaminopropane. The biosynthesis of norspermine and thermospermine from [...] | 0.924 |
PF0854 | PF0853 | PF0854 | PF0853 | Function Code: 5.1 Central Intermediary Metabolism: Degradation of polysaccharides. | 5'-methylthioadenosine phosphorylase II; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.410 |
PF0854 | PF0855 | PF0854 | PF0855 | Function Code: 5.1 Central Intermediary Metabolism: Degradation of polysaccharides. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | 0.773 |
PF0855 | PF0853 | PF0855 | PF0853 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | 5'-methylthioadenosine phosphorylase II; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.410 |
PF0855 | PF0854 | PF0855 | PF0854 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | Function Code: 5.1 Central Intermediary Metabolism: Degradation of polysaccharides. | 0.773 |
PF1349 | PF0853 | PF1349 | PF0853 | Translation initiation factor eIF-2 beta chain; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 5'-methylthioadenosine phosphorylase II; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.926 |
PF1349 | mtaD | PF1349 | PF1538 | Translation initiation factor eIF-2 beta chain; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | N-ethylammeline chlorohydrolase; Catalyzes the deamination of 5-methylthioadenosine and S- adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine. Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family. | 0.473 |
PF1349 | mtnP | PF1349 | PF0016 | Translation initiation factor eIF-2 beta chain; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 5'-methylthioadenosine phosphorylase I; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.926 |
PF1349 | speE | PF1349 | PF0127 | Translation initiation factor eIF-2 beta chain; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to various amine acceptors such as agmatine, cadaverine (1,5-diaminopentane), putrescine (1,4- diaminobutane) and 1,3-diaminopropane. The biosynthesis of norspermine and thermospermine from [...] | 0.612 |
guaAB | PF0852 | PF1516 | PF0852 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | 0.456 |
guaAB | PF0853 | PF1516 | PF0853 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 5'-methylthioadenosine phosphorylase II; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.408 |