STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pgkPhosphoglycerate kinase; Function Code: 6.7 Energy Metabolism: Glycolysis; Belongs to the phosphoglycerate kinase family. (410 aa)    
Predicted Functional Partners:
gap
Glyceraldehyde-3-phosphate dehydrogenase; Active in the presence of NAD and NADP; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
 
 0.999
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
 
 0.997
eno
Enolase (2-phosphoglycerate dehydratase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
 
 0.977
PF0755
Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase; Function Code: 6.7 Energy Metabolism: Glycolysis; (NADP+); Belongs to the aldehyde dehydrogenase family.
 
 0.961
PF1641
Enolase (2-phosphoglycerate dehydratase); Function Code: 6.7 Energy Metabolism: Glycolysis.
 
 
 0.958
gor
Glyceraldehyde-3-phosphate:ferredoxin oxidoreductase; Glycolytic enzyme that acts in the place of glyceraldehyde-3- phosphate dehydrogenase (GAPDH) and phosphoglycerate kinase (PGK). Plays a role in anabolic gluconeogenesis; Belongs to the AOR/FOR family.
 
  
 0.948
apgM
Phosphonopyruvate decarboxylase bcpc; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
    
 0.923
PF1188
Pyruvate kinase; Function Code: 6.7 Energy Metabolism: Glycolysis; Belongs to the pyruvate kinase family.
 
 
 0.904
PF1056
Aspartate-semialdehyde dehydrogenase; Function Code: 1.3 Amino Acid Biosynthesis: Aspartate family.
  
 
 0.812
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
 
  
 0.793
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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