STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
samp2Hypothetical protein; Functions as a protein modifier covalently attached to lysine residues of substrate proteins, as well as a sulfur carrier in tRNA thiolation. The protein modification process is termed sampylation and involves the formation of an isopeptide bond between the SAMP2 C- terminal glycine carboxylate and the epsilon-amino group of lysine residues on target proteins. Is able to form polymeric chains with itself likely at Lys-55, similar to ubiquitin and other ubiquitin-like proteins. May serve as a proteolytic signal in the cell to target proteins for degradation by prot [...] (69 aa)    
Predicted Functional Partners:
PF1070
Hypothetical protein; Metalloprotease that displays desampylase (DSAMP) activity, cleaving ubiquitin-like small archaeal modifier proteins (SAMP1, SAMP2 and SAMP3) from protein conjugates (isopeptide- and linear-linked). Thus, likely regulates sampylation and the pools of 'free' SAMP available for protein modification. In vitro, is also able to cleave non-physiological ubiquitin (Ub) substrates, such as 'Met1-', 'Lys48-', and 'Lys63'-linked Ub dimers (Ub2), and to remove Ub tags from diverse proteins.
  
 
 0.980
PF0003
moeB-like protein; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin.
  
 
 0.785
PF0009
Thiamine biosynthesis protein; Function Code: 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Thiamine; (thiF).
  
 
 0.785
PF1289
Molybdopterin biosynthesis protein moeb; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin.
  
 
 0.785
thiE
Thiamine phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.743
thiC
Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.722
PF1333
Phosphomethylpyrimidine kinase (hmp-phosphate kinase); Function Code: 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Thiamine.
  
    0.690
PF0214
N-type ATP pyrophosphatase; Function Code: 16.0 Unknown.
      
 0.671
PF0273
N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown.
  
 
 0.579
PF1758
N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown.
  
 
 0.579
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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