node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF0003 | PF0009 | PF0003 | PF0009 | moeB-like protein; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin. | Thiamine biosynthesis protein; Function Code: 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Thiamine; (thiF). | 0.937 |
PF0003 | PF1070 | PF0003 | PF1070 | moeB-like protein; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin. | Hypothetical protein; Metalloprotease that displays desampylase (DSAMP) activity, cleaving ubiquitin-like small archaeal modifier proteins (SAMP1, SAMP2 and SAMP3) from protein conjugates (isopeptide- and linear-linked). Thus, likely regulates sampylation and the pools of 'free' SAMP available for protein modification. In vitro, is also able to cleave non-physiological ubiquitin (Ub) substrates, such as 'Met1-', 'Lys48-', and 'Lys63'-linked Ub dimers (Ub2), and to remove Ub tags from diverse proteins. | 0.530 |
PF0003 | PF1289 | PF0003 | PF1289 | moeB-like protein; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin. | Molybdopterin biosynthesis protein moeb; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin. | 0.927 |
PF0003 | PF1333 | PF0003 | PF1333 | moeB-like protein; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin. | Phosphomethylpyrimidine kinase (hmp-phosphate kinase); Function Code: 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Thiamine. | 0.576 |
PF0003 | samp2 | PF0003 | PF1061 | moeB-like protein; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin. | Hypothetical protein; Functions as a protein modifier covalently attached to lysine residues of substrate proteins, as well as a sulfur carrier in tRNA thiolation. The protein modification process is termed sampylation and involves the formation of an isopeptide bond between the SAMP2 C- terminal glycine carboxylate and the epsilon-amino group of lysine residues on target proteins. Is able to form polymeric chains with itself likely at Lys-55, similar to ubiquitin and other ubiquitin-like proteins. May serve as a proteolytic signal in the cell to target proteins for degradation by prot [...] | 0.785 |
PF0003 | thiC | PF0003 | PF1531 | moeB-like protein; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin. | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.641 |
PF0003 | thiE | PF0003 | PF1334 | moeB-like protein; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin. | Thiamine phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.654 |
PF0009 | PF0003 | PF0009 | PF0003 | Thiamine biosynthesis protein; Function Code: 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Thiamine; (thiF). | moeB-like protein; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin. | 0.937 |
PF0009 | PF1070 | PF0009 | PF1070 | Thiamine biosynthesis protein; Function Code: 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Thiamine; (thiF). | Hypothetical protein; Metalloprotease that displays desampylase (DSAMP) activity, cleaving ubiquitin-like small archaeal modifier proteins (SAMP1, SAMP2 and SAMP3) from protein conjugates (isopeptide- and linear-linked). Thus, likely regulates sampylation and the pools of 'free' SAMP available for protein modification. In vitro, is also able to cleave non-physiological ubiquitin (Ub) substrates, such as 'Met1-', 'Lys48-', and 'Lys63'-linked Ub dimers (Ub2), and to remove Ub tags from diverse proteins. | 0.516 |
PF0009 | PF1289 | PF0009 | PF1289 | Thiamine biosynthesis protein; Function Code: 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Thiamine; (thiF). | Molybdopterin biosynthesis protein moeb; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin. | 0.916 |
PF0009 | PF1333 | PF0009 | PF1333 | Thiamine biosynthesis protein; Function Code: 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Thiamine; (thiF). | Phosphomethylpyrimidine kinase (hmp-phosphate kinase); Function Code: 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Thiamine. | 0.576 |
PF0009 | samp2 | PF0009 | PF1061 | Thiamine biosynthesis protein; Function Code: 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Thiamine; (thiF). | Hypothetical protein; Functions as a protein modifier covalently attached to lysine residues of substrate proteins, as well as a sulfur carrier in tRNA thiolation. The protein modification process is termed sampylation and involves the formation of an isopeptide bond between the SAMP2 C- terminal glycine carboxylate and the epsilon-amino group of lysine residues on target proteins. Is able to form polymeric chains with itself likely at Lys-55, similar to ubiquitin and other ubiquitin-like proteins. May serve as a proteolytic signal in the cell to target proteins for degradation by prot [...] | 0.785 |
PF0009 | thiC | PF0009 | PF1531 | Thiamine biosynthesis protein; Function Code: 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Thiamine; (thiF). | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.592 |
PF0009 | thiE | PF0009 | PF1334 | Thiamine biosynthesis protein; Function Code: 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Thiamine; (thiF). | Thiamine phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.659 |
PF0214 | samp2 | PF0214 | PF1061 | N-type ATP pyrophosphatase; Function Code: 16.0 Unknown. | Hypothetical protein; Functions as a protein modifier covalently attached to lysine residues of substrate proteins, as well as a sulfur carrier in tRNA thiolation. The protein modification process is termed sampylation and involves the formation of an isopeptide bond between the SAMP2 C- terminal glycine carboxylate and the epsilon-amino group of lysine residues on target proteins. Is able to form polymeric chains with itself likely at Lys-55, similar to ubiquitin and other ubiquitin-like proteins. May serve as a proteolytic signal in the cell to target proteins for degradation by prot [...] | 0.671 |
PF0273 | samp2 | PF0273 | PF1061 | N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown. | Hypothetical protein; Functions as a protein modifier covalently attached to lysine residues of substrate proteins, as well as a sulfur carrier in tRNA thiolation. The protein modification process is termed sampylation and involves the formation of an isopeptide bond between the SAMP2 C- terminal glycine carboxylate and the epsilon-amino group of lysine residues on target proteins. Is able to form polymeric chains with itself likely at Lys-55, similar to ubiquitin and other ubiquitin-like proteins. May serve as a proteolytic signal in the cell to target proteins for degradation by prot [...] | 0.579 |
PF1070 | PF0003 | PF1070 | PF0003 | Hypothetical protein; Metalloprotease that displays desampylase (DSAMP) activity, cleaving ubiquitin-like small archaeal modifier proteins (SAMP1, SAMP2 and SAMP3) from protein conjugates (isopeptide- and linear-linked). Thus, likely regulates sampylation and the pools of 'free' SAMP available for protein modification. In vitro, is also able to cleave non-physiological ubiquitin (Ub) substrates, such as 'Met1-', 'Lys48-', and 'Lys63'-linked Ub dimers (Ub2), and to remove Ub tags from diverse proteins. | moeB-like protein; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin. | 0.530 |
PF1070 | PF0009 | PF1070 | PF0009 | Hypothetical protein; Metalloprotease that displays desampylase (DSAMP) activity, cleaving ubiquitin-like small archaeal modifier proteins (SAMP1, SAMP2 and SAMP3) from protein conjugates (isopeptide- and linear-linked). Thus, likely regulates sampylation and the pools of 'free' SAMP available for protein modification. In vitro, is also able to cleave non-physiological ubiquitin (Ub) substrates, such as 'Met1-', 'Lys48-', and 'Lys63'-linked Ub dimers (Ub2), and to remove Ub tags from diverse proteins. | Thiamine biosynthesis protein; Function Code: 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Thiamine; (thiF). | 0.516 |
PF1070 | PF1289 | PF1070 | PF1289 | Hypothetical protein; Metalloprotease that displays desampylase (DSAMP) activity, cleaving ubiquitin-like small archaeal modifier proteins (SAMP1, SAMP2 and SAMP3) from protein conjugates (isopeptide- and linear-linked). Thus, likely regulates sampylation and the pools of 'free' SAMP available for protein modification. In vitro, is also able to cleave non-physiological ubiquitin (Ub) substrates, such as 'Met1-', 'Lys48-', and 'Lys63'-linked Ub dimers (Ub2), and to remove Ub tags from diverse proteins. | Molybdopterin biosynthesis protein moeb; Function Code: 2.5 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Molybdopterin. | 0.517 |
PF1070 | samp2 | PF1070 | PF1061 | Hypothetical protein; Metalloprotease that displays desampylase (DSAMP) activity, cleaving ubiquitin-like small archaeal modifier proteins (SAMP1, SAMP2 and SAMP3) from protein conjugates (isopeptide- and linear-linked). Thus, likely regulates sampylation and the pools of 'free' SAMP available for protein modification. In vitro, is also able to cleave non-physiological ubiquitin (Ub) substrates, such as 'Met1-', 'Lys48-', and 'Lys63'-linked Ub dimers (Ub2), and to remove Ub tags from diverse proteins. | Hypothetical protein; Functions as a protein modifier covalently attached to lysine residues of substrate proteins, as well as a sulfur carrier in tRNA thiolation. The protein modification process is termed sampylation and involves the formation of an isopeptide bond between the SAMP2 C- terminal glycine carboxylate and the epsilon-amino group of lysine residues on target proteins. Is able to form polymeric chains with itself likely at Lys-55, similar to ubiquitin and other ubiquitin-like proteins. May serve as a proteolytic signal in the cell to target proteins for degradation by prot [...] | 0.980 |