STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadKHypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (277 aa)    
Predicted Functional Partners:
cobB
Transcriptional regulatory protein, sir2; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily.
  
 
 0.970
nadE
NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.963
fbpA
Extragenic suppressor; Catalyzes the conversion of D-fructose 1,6-bisphosphate to D- fructose 6-phosphate. In vitro, has also weak activity with inositol-1- phosphate, glucose-1-phosphate and glycerol-2-phosphate. Belongs to the inositol monophosphatase superfamily. FBPase class 4 family.
 
  
 0.931
PF0458
Nucleotidyltransferase; Function Code: 16.0 Unknown.
    
 0.922
PF1102
Bifunctional short chain isoprenyl diphosphate synthase; Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the FPP/GGPP synthase family.
 
 
 
 0.838
PF1904
Nicotinate-nucleotide pyrophosphorylase; Function Code: 2.9 Biosynthesis of Cofactors: Pyridine nucleotides: NAD & NADP.
 
   
 0.709
PF0169
Putative nucleolar protein III (nol1-nop2-sun family); Function Code: 4.2 Cellular Processes: Cell division; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
    0.655
nadB
L-aspartate oxidase (quinolinate synthetase); Catalyzes the oxidation of L-aspartate to iminoaspartate.
      
 0.613
rnj
Hypothetical protein; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
  
  
 0.610
uppS
Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
 
   
 0.586
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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