node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF0169 | nadK | PF0169 | PF1103 | Putative nucleolar protein III (nol1-nop2-sun family); Function Code: 4.2 Cellular Processes: Cell division; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.655 |
PF0458 | PF1904 | PF0458 | PF1904 | Nucleotidyltransferase; Function Code: 16.0 Unknown. | Nicotinate-nucleotide pyrophosphorylase; Function Code: 2.9 Biosynthesis of Cofactors: Pyridine nucleotides: NAD & NADP. | 0.963 |
PF0458 | cobB | PF0458 | PF1154 | Nucleotidyltransferase; Function Code: 16.0 Unknown. | Transcriptional regulatory protein, sir2; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.960 |
PF0458 | nadE | PF0458 | PF0098 | Nucleotidyltransferase; Function Code: 16.0 Unknown. | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.956 |
PF0458 | nadK | PF0458 | PF1103 | Nucleotidyltransferase; Function Code: 16.0 Unknown. | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.922 |
PF1102 | nadK | PF1102 | PF1103 | Bifunctional short chain isoprenyl diphosphate synthase; Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the FPP/GGPP synthase family. | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.838 |
PF1102 | rnj | PF1102 | PF1101 | Bifunctional short chain isoprenyl diphosphate synthase; Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the FPP/GGPP synthase family. | Hypothetical protein; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily. | 0.944 |
PF1102 | uppS | PF1102 | PF1599 | Bifunctional short chain isoprenyl diphosphate synthase; Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the FPP/GGPP synthase family. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. | 0.982 |
PF1904 | PF0458 | PF1904 | PF0458 | Nicotinate-nucleotide pyrophosphorylase; Function Code: 2.9 Biosynthesis of Cofactors: Pyridine nucleotides: NAD & NADP. | Nucleotidyltransferase; Function Code: 16.0 Unknown. | 0.963 |
PF1904 | cobB | PF1904 | PF1154 | Nicotinate-nucleotide pyrophosphorylase; Function Code: 2.9 Biosynthesis of Cofactors: Pyridine nucleotides: NAD & NADP. | Transcriptional regulatory protein, sir2; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.400 |
PF1904 | nadB | PF1904 | PF1976 | Nicotinate-nucleotide pyrophosphorylase; Function Code: 2.9 Biosynthesis of Cofactors: Pyridine nucleotides: NAD & NADP. | L-aspartate oxidase (quinolinate synthetase); Catalyzes the oxidation of L-aspartate to iminoaspartate. | 0.478 |
PF1904 | nadE | PF1904 | PF0098 | Nicotinate-nucleotide pyrophosphorylase; Function Code: 2.9 Biosynthesis of Cofactors: Pyridine nucleotides: NAD & NADP. | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.825 |
PF1904 | nadK | PF1904 | PF1103 | Nicotinate-nucleotide pyrophosphorylase; Function Code: 2.9 Biosynthesis of Cofactors: Pyridine nucleotides: NAD & NADP. | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.709 |
cobB | PF0458 | PF1154 | PF0458 | Transcriptional regulatory protein, sir2; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | Nucleotidyltransferase; Function Code: 16.0 Unknown. | 0.960 |
cobB | PF1904 | PF1154 | PF1904 | Transcriptional regulatory protein, sir2; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | Nicotinate-nucleotide pyrophosphorylase; Function Code: 2.9 Biosynthesis of Cofactors: Pyridine nucleotides: NAD & NADP. | 0.400 |
cobB | nadB | PF1154 | PF1976 | Transcriptional regulatory protein, sir2; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | L-aspartate oxidase (quinolinate synthetase); Catalyzes the oxidation of L-aspartate to iminoaspartate. | 0.623 |
cobB | nadE | PF1154 | PF0098 | Transcriptional regulatory protein, sir2; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.930 |
cobB | nadK | PF1154 | PF1103 | Transcriptional regulatory protein, sir2; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.970 |
fbpA | nadK | PF2014 | PF1103 | Extragenic suppressor; Catalyzes the conversion of D-fructose 1,6-bisphosphate to D- fructose 6-phosphate. In vitro, has also weak activity with inositol-1- phosphate, glucose-1-phosphate and glycerol-2-phosphate. Belongs to the inositol monophosphatase superfamily. FBPase class 4 family. | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.931 |
nadB | PF1904 | PF1976 | PF1904 | L-aspartate oxidase (quinolinate synthetase); Catalyzes the oxidation of L-aspartate to iminoaspartate. | Nicotinate-nucleotide pyrophosphorylase; Function Code: 2.9 Biosynthesis of Cofactors: Pyridine nucleotides: NAD & NADP. | 0.478 |