STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobBTranscriptional regulatory protein, sir2; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. (297 aa)    
Predicted Functional Partners:
gdhA
Glutamate dehydrogenase; Function Code: 5.6 Central Intermediary Metabolism: Other; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 0.974
nadK
Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.970
PF0458
Nucleotidyltransferase; Function Code: 16.0 Unknown.
   
 
 0.960
nadE
NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.930
PF1105
Pyrazinamidase/nicotinamidase pxnc; Function Code: 2.1 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: General.
  
 0.930
PF1151
Putative multisubunit Na+/H+ antiporter; Function Code: 14.6 Transport and Binding Proteins: Other; (mnhG).
 
     0.800
PF1153
Putative multisubunit Na+/H+ antiporter; Function Code: 14.6 Transport and Binding Proteins: Other; (mnhC).
       0.790
PF1147
Putative multisubunit Na+/H+ antiporter; Function Code: 14.6 Transport and Binding Proteins: Other.
       0.773
PF1148
Putative multisubunit Na+/H+ antiporter; Function Code: 14.6 Transport and Binding Proteins: Other.
       0.773
PF1149
Putative multisubunit Na+/H+ antiporter; Function Code: 14.6 Transport and Binding Proteins: Other.
       0.773
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.