STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mbhLMbh12 membrane bound hydrogenase alpha (NADH dehydrogenase); Alpha subunit of a hydrogen-evolving hydrogenase that utilizes protons both as a substrate for hydrogen production and proton translocation. Acts by coupling the redox reaction via ferredoxin and iron-sulfur (Fe-S) clusters to proton translocation across the membrane thereby conserving the redox energy in a proton gradient. (427 aa)    
Predicted Functional Partners:
mbhJ
Mbh10 NADH dehydrogenase subunit (like cCoL, EchC, HycH); Probable subunit of a hydrogen-evolving hydrogenase that utilizes protons both as a substrate for hydrogen production and proton translocation. Acts by coupling the redox reaction via ferredoxin and iron-sulfur (Fe-S) clusters to proton translocation across the membrane, thereby conserving the redox energy in a proton gradient.
 0.999
mbhK
Mbh11 membrane bound hydrogenase beta (NADH dehydrogenase); Beta subunit of a hydrogen-evolving hydrogenase that utilizes protons both as a substrate for hydrogen production and proton translocation. Acts by coupling the redox reaction via ferredoxin and iron-sulfur (Fe-S) clusters to proton translocation across the membrane thereby conserving the redox energy in a proton gradient.
 
 
 0.999
PF1435
Mbh13 NADH dehydrogenase subunit (like HycD, CooK, echB); Function Code: 6.4 Energy Metabolism: Electron transport.
 
 
 0.999
PF1436
Mbh14 iron-sulfur protein (like HycF, EchF, CooX); Function Code: 6.4 Energy Metabolism: Electron transport.
 
 
 0.996
PF1430
Mbh8 NADH dehydrogenase subunit - integral membrane protein (like CooM); Function Code: 6.4 Energy Metabolism: Electron transport.
 
 
 0.994
PF1431
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
   
 
 0.984
PF1423
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
  
 
 0.982
PF1425
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
 
 
 0.976
PF1428
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
 
 
   0.972
PF1429
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
  
   0.972
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.