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thi4 protein (Pyrococcus furiosus) - STRING interaction network
"thi4" - Thiamine thiazole synthase in Pyrococcus furiosus
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Predicted Interactions
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thi4Thiamine thiazole synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur; Belongs to the THI4 family (252 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (182 aa)
         
  0.897
PF1607
AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO; Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily (503 aa)
         
  0.896
PF0122
Ribose 1,5-bisphosphate isomerase; Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO (By similarity); Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily (321 aa)
           
  0.896
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family (265 aa)
         
  0.883
thiC
Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction; Belongs to the ThiC family (429 aa)
   
   
  0.855
thiE
Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP); Belongs to the thiamine-phosphate synthase family (207 aa)
         
  0.799
PF0818
Aminohydrolase; Function Code- 6.1 Energy Metabolism- Amino acids and amines (335 aa)
     
   
  0.753
PF1333
Phosphomethylpyrimidine kinase (Hmp-phosphate kinase); Function Code- 2.8 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers- Thiamine (451 aa)
   
   
  0.664
PF0280
Uncharacterized protein; Function Code- 16.1 Conserved Hypothetical (104 aa)
           
  0.608
thy1
Flavin-dependent thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant; Belongs to the thymidylate synthase ThyX family (244 aa)
           
  0.607
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus DSM3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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