STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lrpATranscriptional regulatory protein, asnC family; Negatively regulates its own transcription. Binds to a 46- base pair sequence that overlaps the transcriptional start site of its own promoter. (141 aa)    
Predicted Functional Partners:
tbp
TATA-box-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
      
 0.777
tfb
Transcription initiation factor IIB chain b; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
      
 0.764
PF0322
Hypothetical protein; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family.
   
  
 0.703
fau-1
Putative RNase E; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Preferentially cleaves UA sequences in the 5' precursor region of 5S rRNA. Binds to RNA in loop regions with AU-rich sequences. Binds to the consensus sequence GGC(U/A)(U/A)U(U/C) in vitro.
   
  
 0.624
PF0095
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
      
 0.613
gdhA
Glutamate dehydrogenase; Function Code: 5.6 Central Intermediary Metabolism: Other; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
  
 0.580
uppS
Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
       0.507
PF1600
Ferripyochelin binding protein; Function Code: 16 Unknown:.
       0.507
srp54
Signal recognition particle protein srp54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
  
  
 0.464
PF0851
Iron-dependent repressor; Function Code: 10 Regulatory Functions: REGULATORY FUNCTIONS.
  
  
 0.403
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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