STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gdhAGlutamate dehydrogenase; Function Code: 5.6 Central Intermediary Metabolism: Other; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (420 aa)    
Predicted Functional Partners:
cobB
Transcriptional regulatory protein, sir2; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily.
  
 0.974
PF0202
Isocitrate dehydrogenase; Function Code: 6.10 Energy Metabolism: TCA cycle.
   
 0.960
glnA
Glutamine synthetase i; Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
  
 
 0.950
PF1852
Glutamate synthase small subunit; Function Code: 5.6 Central Intermediary Metabolism: Other.
  
 0.947
PF1910
Glutamate synthase; Function Code: 4.5 Cellular Processes: Detoxification; (gltA).
  
 0.947
cpkA
Carbamate kinase-like carbamoylphosphate synthetase; Carbamate kinase that plays a biosynthetic role in that it produces carbamoyl-phosphate.
     
 0.943
PF0522
Aspartate transaminase; Function Code: 1.3 Amino Acid Biosynthesis: Aspartate family.
  
 
 0.920
PF1497
Putative transaminase; Function Code: 1.3 Amino Acid Biosynthesis: Aspartate family.
  
 
 0.920
PF1702
Aspartate aminotransferase; Function Code: 1.3 Amino Acid Biosynthesis: Aspartate family; (aspB-2).
  
 
 0.918
hcp
Prismane protein homolog; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
   
 0.912
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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