STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdaDHypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the PdaD family. (158 aa)    
Predicted Functional Partners:
PF1957
Agmatinase; Function Code: 5.3 Central Intermediary Metabolism: Polyamine biosynthesis; (speB); Belongs to the arginase family.
 
  
 0.932
PF0499
Metal-binding protein; Similar to arginase 1 which binds 2 manganeses; Function Code: 16.0 Unknown; Belongs to the arginase family.
 
  
 0.931
argH
Argininosuccinate lyase; Function Code: 1.4 Amino Acid Biosynthesis: Glutamate family.
     
 0.861
PF1848
3-hydroxy-3-methylglutaryl-coenzyme a reductase (hmg-CoAreductase); Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the HMG-CoA reductase family.
      
 0.752
speE
Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to various amine acceptors such as agmatine, cadaverine (1,5-diaminopentane), putrescine (1,4- diaminobutane) and 1,3-diaminopropane. The biosynthesis of norspermine and thermospermine from [...]
 
 
 0.749
PF1624
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
     
 0.683
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
      
 0.668
PF1017
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
     
 0.657
speH
Hypothetical protein; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
 
  
 0.612
pyrF
Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
     
 0.542
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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