node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF0499 | PF1957 | PF0499 | PF1957 | Metal-binding protein; Similar to arginase 1 which binds 2 manganeses; Function Code: 16.0 Unknown; Belongs to the arginase family. | Agmatinase; Function Code: 5.3 Central Intermediary Metabolism: Polyamine biosynthesis; (speB); Belongs to the arginase family. | 0.926 |
PF0499 | pdaD | PF0499 | PF1623 | Metal-binding protein; Similar to arginase 1 which binds 2 manganeses; Function Code: 16.0 Unknown; Belongs to the arginase family. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the PdaD family. | 0.931 |
PF0499 | speE | PF0499 | PF0127 | Metal-binding protein; Similar to arginase 1 which binds 2 manganeses; Function Code: 16.0 Unknown; Belongs to the arginase family. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to various amine acceptors such as agmatine, cadaverine (1,5-diaminopentane), putrescine (1,4- diaminobutane) and 1,3-diaminopropane. The biosynthesis of norspermine and thermospermine from [...] | 0.945 |
PF1017 | panB | PF1017 | PF1143 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.409 |
PF1017 | pdaD | PF1017 | PF1623 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the PdaD family. | 0.657 |
PF1017 | speE | PF1017 | PF0127 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to various amine acceptors such as agmatine, cadaverine (1,5-diaminopentane), putrescine (1,4- diaminobutane) and 1,3-diaminopropane. The biosynthesis of norspermine and thermospermine from [...] | 0.544 |
PF1624 | pdaD | PF1624 | PF1623 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the PdaD family. | 0.683 |
PF1848 | pdaD | PF1848 | PF1623 | 3-hydroxy-3-methylglutaryl-coenzyme a reductase (hmg-CoAreductase); Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the HMG-CoA reductase family. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the PdaD family. | 0.752 |
PF1848 | pyrF | PF1848 | PF1114 | 3-hydroxy-3-methylglutaryl-coenzyme a reductase (hmg-CoAreductase); Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the HMG-CoA reductase family. | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.691 |
PF1957 | PF0499 | PF1957 | PF0499 | Agmatinase; Function Code: 5.3 Central Intermediary Metabolism: Polyamine biosynthesis; (speB); Belongs to the arginase family. | Metal-binding protein; Similar to arginase 1 which binds 2 manganeses; Function Code: 16.0 Unknown; Belongs to the arginase family. | 0.926 |
PF1957 | pdaD | PF1957 | PF1623 | Agmatinase; Function Code: 5.3 Central Intermediary Metabolism: Polyamine biosynthesis; (speB); Belongs to the arginase family. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the PdaD family. | 0.932 |
PF1957 | speE | PF1957 | PF0127 | Agmatinase; Function Code: 5.3 Central Intermediary Metabolism: Polyamine biosynthesis; (speB); Belongs to the arginase family. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to various amine acceptors such as agmatine, cadaverine (1,5-diaminopentane), putrescine (1,4- diaminobutane) and 1,3-diaminopropane. The biosynthesis of norspermine and thermospermine from [...] | 0.954 |
argH | pdaD | PF0208 | PF1623 | Argininosuccinate lyase; Function Code: 1.4 Amino Acid Biosynthesis: Glutamate family. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the PdaD family. | 0.861 |
argH | speE | PF0208 | PF0127 | Argininosuccinate lyase; Function Code: 1.4 Amino Acid Biosynthesis: Glutamate family. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to various amine acceptors such as agmatine, cadaverine (1,5-diaminopentane), putrescine (1,4- diaminobutane) and 1,3-diaminopropane. The biosynthesis of norspermine and thermospermine from [...] | 0.476 |
panB | PF1017 | PF1143 | PF1017 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | 0.409 |
panB | pdaD | PF1143 | PF1623 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the PdaD family. | 0.668 |
pdaD | PF0499 | PF1623 | PF0499 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the PdaD family. | Metal-binding protein; Similar to arginase 1 which binds 2 manganeses; Function Code: 16.0 Unknown; Belongs to the arginase family. | 0.931 |
pdaD | PF1017 | PF1623 | PF1017 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the PdaD family. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | 0.657 |
pdaD | PF1624 | PF1623 | PF1624 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the PdaD family. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | 0.683 |
pdaD | PF1848 | PF1623 | PF1848 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the PdaD family. | 3-hydroxy-3-methylglutaryl-coenzyme a reductase (hmg-CoAreductase); Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the HMG-CoA reductase family. | 0.752 |