node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF0291 | PF0293 | PF0291 | PF0293 | Prephenate dehydratase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family. | Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1). | 0.965 |
PF0291 | hisA | PF0291 | PF1662 | Prephenate dehydratase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family. | N-(5'-phospho-d-ribosylformimino)-5-amino-1- (5''-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family. | 0.535 |
PF0291 | hisC | PF0291 | PF1665 | Prephenate dehydratase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family. | Putative histidinol-phosphate aminotransferase (imidazole; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family. | 0.935 |
PF0291 | hisG | PF0291 | PF1658 | Prephenate dehydratase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.462 |
PF0291 | hisH | PF0291 | PF1661 | Prephenate dehydratase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.504 |
PF0293 | PF0291 | PF0293 | PF0291 | Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1). | Prephenate dehydratase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family. | 0.965 |
PF0293 | cobQ | PF0293 | PF0301 | Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1). | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.956 |
PF0293 | hisA | PF0293 | PF1662 | Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1). | N-(5'-phospho-d-ribosylformimino)-5-amino-1- (5''-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family. | 0.872 |
PF0293 | hisB | PF0293 | PF1660 | Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1). | Imidazoleglycerol-phosphate dehydratase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family. | 0.988 |
PF0293 | hisC | PF0293 | PF1665 | Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1). | Putative histidinol-phosphate aminotransferase (imidazole; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family. | 0.915 |
PF0293 | hisD | PF0293 | PF1659 | Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1). | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.899 |
PF0293 | hisF | PF0293 | PF1663 | Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1). | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.883 |
PF0293 | hisG | PF0293 | PF1658 | Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1). | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.880 |
PF0293 | hisH | PF0293 | PF1661 | Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1). | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.885 |
PF0293 | hisI | PF0293 | PF1664 | Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1). | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-atp; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; In the C-terminal section; belongs to the PRA-PH family. | 0.886 |
cobQ | PF0293 | PF0301 | PF0293 | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1). | 0.956 |
cobQ | hisC | PF0301 | PF1665 | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Putative histidinol-phosphate aminotransferase (imidazole; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family. | 0.927 |
hisA | PF0291 | PF1662 | PF0291 | N-(5'-phospho-d-ribosylformimino)-5-amino-1- (5''-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family. | Prephenate dehydratase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family. | 0.535 |
hisA | PF0293 | PF1662 | PF0293 | N-(5'-phospho-d-ribosylformimino)-5-amino-1- (5''-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family. | Histidinol-phosphate aminotransferase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family; (hisC-1). | 0.872 |
hisA | hisB | PF1662 | PF1660 | N-(5'-phospho-d-ribosylformimino)-5-amino-1- (5''-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family. | Imidazoleglycerol-phosphate dehydratase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family. | 0.999 |