STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PF1701Chorismate mutase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family. (76 aa)    
Predicted Functional Partners:
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.995
PF1703
Prephenate dehydrogenase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family.
  
 
 0.986
PF0291
Prephenate dehydratase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family.
  
 
 0.964
PF1708
Anthranilate synthase component II; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpG).
  
 
 0.964
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
  
 
 0.964
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
  
 0.954
rpl29
Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl29P).
  
    0.895
PF1704
Function Code: 16.4 Hypothetical.
  
  
 0.866
PF1702
Aspartate aminotransferase; Function Code: 1.3 Amino Acid Biosynthesis: Aspartate family; (aspB-2).
  
  
 0.858
dapAL
Putative dihydrodipicolinate synthase; Function Code: 1.3 Amino Acid Biosynthesis: Aspartate family; (dapA); Belongs to the DapA family.
  
  
 0.809
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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