node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF1708 | aroC | PF1708 | PF1700 | Anthranilate synthase component II; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpG). | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.962 |
PF1708 | glyA | PF1708 | PF1778 | Anthranilate synthase component II; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpG). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.430 |
PF1708 | trpA | PF1708 | PF1705 | Anthranilate synthase component II; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpG). | Tryptophan synthetase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate; Belongs to the TrpA family. | 0.997 |
PF1708 | trpB1 | PF1708 | PF1706 | Anthranilate synthase component II; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpG). | Tryptophan synthase, subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.998 |
PF1708 | trpB2 | PF1708 | PF1592 | Anthranilate synthase component II; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpG). | Tryptophan synthase, subunit beta homolog; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.482 |
PF1708 | trpC | PF1708 | PF1711 | Anthranilate synthase component II; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpG). | Indoleglycerol phosphate synthase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpC); Belongs to the TrpC family. | 0.999 |
PF1708 | trpD | PF1708 | PF1710 | Anthranilate synthase component II; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpG). | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
PF1708 | trpE | PF1708 | PF1709 | Anthranilate synthase component II; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpG). | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.999 |
PF1708 | trpF | PF1708 | PF1707 | Anthranilate synthase component II; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpG). | Phosphoribosyl anthranilate isomerase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpF); Belongs to the TrpF family. | 0.998 |
PF1921 | glyA | PF1921 | PF1778 | Phosphoserine phosphatase; Function Code: 1.6 Amino Acid Biosynthesis: Serine family; (serB). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
PF1921 | trpA | PF1921 | PF1705 | Phosphoserine phosphatase; Function Code: 1.6 Amino Acid Biosynthesis: Serine family; (serB). | Tryptophan synthetase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate; Belongs to the TrpA family. | 0.908 |
PF1921 | trpB1 | PF1921 | PF1706 | Phosphoserine phosphatase; Function Code: 1.6 Amino Acid Biosynthesis: Serine family; (serB). | Tryptophan synthase, subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.927 |
PF1921 | trpB2 | PF1921 | PF1592 | Phosphoserine phosphatase; Function Code: 1.6 Amino Acid Biosynthesis: Serine family; (serB). | Tryptophan synthase, subunit beta homolog; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
PF1921 | trpD | PF1921 | PF1710 | Phosphoserine phosphatase; Function Code: 1.6 Amino Acid Biosynthesis: Serine family; (serB). | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.436 |
aroC | PF1708 | PF1700 | PF1708 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase component II; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpG). | 0.962 |
aroC | glyA | PF1700 | PF1778 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.417 |
aroC | trpA | PF1700 | PF1705 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthetase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate; Belongs to the TrpA family. | 0.864 |
aroC | trpB1 | PF1700 | PF1706 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase, subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.786 |
aroC | trpC | PF1700 | PF1711 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Indoleglycerol phosphate synthase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family; (trpC); Belongs to the TrpC family. | 0.683 |
aroC | trpD | PF1700 | PF1710 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.774 |