STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfkCADP-dependent phosphofructokinase; Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor. As a phosphoryl group donor, ADP can be replaced by GDP, ATP, and GTP to a limited extent; Belongs to the carbohydrate kinase PfkC family. (454 aa)    
Predicted Functional Partners:
glkA
ADP-dependent glucokinase; Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate. Can also use CDP as the phosphoryl group donor and D-1,5-anhydroglucitol as the phosphoryl group acceptor.
  
  
0.931
pgiA
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
    
 0.920
PF1688
Transketolase N-terminal section; Function Code: 6.8 Energy Metabolism: Pentose phosphate pathway.
  
  
  0.914
fba
Possible 1,6-fructose biphosphate aldolase; Function Code: 6.7 Energy Metabolism: Glycolysis; Belongs to the DeoC/FbaB aldolase family.
    
 0.914
PF1689
Transketolase C-terminal section; Function Code: 6.8 Energy Metabolism: Pentose phosphate pathway.
  
  
  0.911
fbp
Hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
     
 0.910
PF0588
Phospho-sugar mutase; Function Code: 3.2 Cell Envelope: Surface polysaccharides, lipopolysaccharides and antigens.
    
 0.905
PF0220
Hexulose-6-phosphate synthase (d-arabino 3-hexulose 6-phosphate formaldehyde lyase); Function Code: 6.9 Energy Metabolism: Sugars.
     
  0.900
PF0755
Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase; Function Code: 6.7 Energy Metabolism: Glycolysis; (NADP+); Belongs to the aldehyde dehydrogenase family.
     
 0.832
PF0024
Putative glycerate kinase; Function Code: 5.6 Central Intermediary Metabolism: Other.
     
 0.820
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.