STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acdBIacetyl-CoA synthetase; Catalyzes the reversible formation of acetate and ATP from acetyl-CoA by using ADP and phosphate. Can use other substrates such as isobutyryl-CoA, propionyl-CoA and butyryl-CoA, but not indoleacetyl- CoA, phenylacetyl-CoA or succinyl-CoA. Seems to be involved primarily in the conversion of acetyl-CoA to acetate. Participates in the degradation of branched-chain amino acids via branched-chain-acyl-CoA esters; Belongs to the acetate CoA ligase beta subunit family. (232 aa)    
Predicted Functional Partners:
acdAI
Acetyl coenzyme A synthetase (ADP forming); Catalyzes the reversible formation of acetate and ATP from acetyl-CoA by using ADP and phosphate. Can use other substrates such as isobutyryl-CoA, propionyl-CoA and butyryl-CoA, but not indoleacetyl- CoA, phenylacetyl-CoA or succinyl-CoA. Seems to be involved primarily in the conversion of acetyl-CoA to acetate. Participates in the degradation of branched-chain amino acids via branched-chain-acyl-CoA esters; Belongs to the acetate CoA ligase alpha subunit family.
 
 0.999
acdAII
Hypothetical protein; Catalyzes the reversible formation of acetate and ATP from acetyl-CoA by using ADP and phosphate. Can use other substrates such as phenylacetyl-CoA, indoleacetyl-CoA and isobutyryl-CoA, but not succinyl-CoA. Seems to be involved primarily in the degradation of aryl-CoA esters to the corresponding acids. Participates in the conversion of acetyl-CoA to acetate and in the degradation of branched- chain amino acids via branched-chain-acyl-CoA esters. Belongs to the acetate CoA ligase alpha subunit family.
 
 0.998
PF0233
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
 
 
 0.988
PF1838
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
 
 
 0.988
PF1085
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
 
 
 0.987
porD
Pyruvate ferredoxin oxidoreductase subunit delta; Function Code: 6.5 Energy Metabolism: Fermentation.
    
 0.916
PF0973
Acetyl CoA synthase; Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; (acaB).
  
 
 0.914
porA
Pyruvate ferredoxin oxidoreductase subunit alpha-2; Function Code: 6.5 Energy Metabolism: Fermentation.
  
 
 0.911
porB
Pyruvate ferredoxin oxidoreductase subunit beta-2; Function Code: 6.5 Energy Metabolism: Fermentation.
    
 0.905
porG
Pyruvate ferredoxin oxidoreductase/2-ketovalerate ferredoxin oxidoreductase gamma subunit; Function Code: 6.5 Energy Metabolism: Fermentation.
    
 0.905
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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