STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PF1791Small nucleolar rnp gar1-like protein; Function Code: 12.3 Transcription: RNA Processing. (104 aa)    
Predicted Functional Partners:
nop10
Hypothetical protein; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA; Belongs to the NOP10 family.
   
 0.999
truB
Centromere binding protein homolog/pseudouridine synthase; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
  
 0.999
rpl7ae
LSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. Component of the 70S ribosome. Component of a box C/D small ribonucleoprotein (sRNP) particle that is involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site- specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic d [...]
  
 0.995
PF0060
NOP5/NOP56 related protein; Function Code: 12.3 Transcription: RNA processing.
 
 
 0.903
PF1792
5'-cyclic-nucleotide phosphodiesterase cpda homolog; Function Code: 10.0 Regulatory functions: regulatory functions.
       0.812
PF1790
Transcriptional regulatory protein arsR family; Function Code: 10.0 Regulatory functions: regulatory functions.
 
     0.801
PF0499
Metal-binding protein; Similar to arginase 1 which binds 2 manganeses; Function Code: 16.0 Unknown; Belongs to the arginase family.
      
 0.790
PF1826
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
  
   0.708
PF1940
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
   
 
 0.699
guaAB
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.677
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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