STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PF1886Sugar kinase; Function Code: 3.2 Cell Envelope: Surface polysaccharides, lipopolysaccharides and antigens; Belongs to the carbohydrate kinase PfkB family. (294 aa)    
Predicted Functional Partners:
hisA
N-(5'-phospho-d-ribosylformimino)-5-amino-1- (5''-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family.
  
  
 0.874
PF1885
Glycosyl transferase; Function Code: 3.2 Cell Envelope: Surface polysaccharides, lipopolysaccharides and antigens.
 
  
 0.770
kae1
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
     
 0.756
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
  
  
 0.674
PF0523
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
      
 0.593
glkA
ADP-dependent glucokinase; Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate. Can also use CDP as the phosphoryl group donor and D-1,5-anhydroglucitol as the phosphoryl group acceptor.
  
   
 0.588
PF1884
Putative ABC transporter (ATP-binding protein); Function Code: 14.1 Transport and Binding Proteins: General.
       0.586
PF1005
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
 
  
 0.573
PF0554
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
 
  
 0.522
PF1383
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
  
  
 0.510
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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