STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PF1904Nicotinate-nucleotide pyrophosphorylase; Function Code: 2.9 Biosynthesis of Cofactors: Pyridine nucleotides: NAD & NADP. (389 aa)    
Predicted Functional Partners:
PF1105
Pyrazinamidase/nicotinamidase pxnc; Function Code: 2.1 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: General.
 
 0.992
PF0458
Nucleotidyltransferase; Function Code: 16.0 Unknown.
    
 0.963
PF1978
Nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase (decarboxylating)); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
   
 0.960
nadE
NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
 
  
 0.825
hisF
Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
     
 0.801
hisA
N-(5'-phospho-d-ribosylformimino)-5-amino-1- (5''-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function Code: 1.7 Amino Acid Biosynthesis: Histidine family.
  
  
 0.768
nadK
Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
   
 0.709
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
     
 0.649
PF1017
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
     
 0.649
PF1903
Putative translation initiation factor (IF-2 homolog); Function Code: 13.6 Translation: Translation factors.
 
     0.603
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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