STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PF1974Thermosome, single subunit; Function Code: 4.3 Cellular Processes: Chaperones; Belongs to the TCP-1 chaperonin family. (549 aa)    
Predicted Functional Partners:
pfdA
Hypothetical protein; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
   
 
 0.994
PF0467
ATP-dependent protease LA (lon); Function Code: 13.2 Translation: Degradation of proteins, peptides, and glycopeptides; Belongs to the peptidase S16 family.
 
 
 0.861
eif5a
Translation initiation factor eIF-5a; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.
 
 
 0.860
tbp
TATA-box-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
 
 
 0.852
infB
Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity).
  
 
 0.821
psmB1
Proteasome, subunit beta (multicatalytic endopeptidase complex beta subunit); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
 0.820
fusA
Elongation factor 2 (EF-2); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...]
 
 
 0.820
PF1883
Small heat shock protein; Function Code: 4.3 Cellular Processes: Chaperones; (class I); Belongs to the small heat shock protein (HSP20) family.
  
  
 0.809
psmA
Proteasome, subunit alpha (multicatalytic endopeptidase complex alpha subunit); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 
 0.798
eIF1A
Translation initiation factor eIF-1a; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
 
 
 0.796
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.