STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PF2015ATP-dependent RNA helicase, putative; Function Code: 12.3 Transcription: RNA processing. (764 aa)    
Predicted Functional Partners:
PF2020
Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair.
 
 
 0.877
PF2013
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
 
     0.856
rpl1
LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release.
    
 0.836
fbpA
Extragenic suppressor; Catalyzes the conversion of D-fructose 1,6-bisphosphate to D- fructose 6-phosphate. In vitro, has also weak activity with inositol-1- phosphate, glucose-1-phosphate and glycerol-2-phosphate. Belongs to the inositol monophosphatase superfamily. FBPase class 4 family.
  
    0.789
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 
 0.733
rpl40e
Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl40E).
  
 
  0.707
fusA
Elongation factor 2 (EF-2); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...]
 
   
 0.703
smc
Chromosome segregation protein smc; Required for chromosome condensation and partitioning (By similarity). Binds single-stranded but not double-stranded DNA.
  
 
 0.653
pol
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity.
 
 
 0.638
radA
Recombinase, radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
  
 
 0.615
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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