STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mlg_0591PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: csa:Csal_2048 methylenetetrahydrofolate dehydrogenase (NADP+). (286 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.983
Mlg_0611
KEGG: tcx:Tcr_0439 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein.
  
 
 0.974
Mlg_2627
TIGRFAM: methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein; KEGG: mca:MCA2844 methionyl-tRNA formyltransferase.
 
 
 0.970
Mlg_2576
TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: noc:Noc_0500 glycine cleavage system T protein.
  
 
 0.967
Mlg_0515
Phosphoribosylglycinamide formyltransferase; KEGG: pae:PA0944 phosphoribosylaminoimidazole synthetase; TIGRFAM: phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein.
 
 
 0.965
Mlg_2538
PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: pfl:PFL_5971 5-formyltetrahydrofolate cyclo-ligase family protein.
 
  
 0.947
Mlg_2099
TIGRFAM: formyltetrahydrofolate deformylase; PFAM: formyl transferase domain protein; amino acid-binding ACT domain protein; KEGG: bth:BT1381 formyltetrahydrofolate deformylase.
  
 
 0.943
Mlg_2264
KEGG: nmu:Nmul_A2539 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase.
    
 0.941
Mlg_0693
KEGG: noc:Noc_0612 exodeoxyribonuclease VII; TIGRFAM: exodeoxyribonuclease VII, large subunit; PFAM: Exonuclease VII, large subunit; nucleic acid binding, OB-fold, tRNA/helicase-type.
 
    0.935
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.932
Your Current Organism:
Alkalilimnicola ehrlichii
NCBI taxonomy Id: 187272
Other names: A. ehrlichii MLHE-1, Alkalilimnicola ehrlichii MLHE-1, Alkalilimnicola ehrlichii str. MLHE-1, Alkalilimnicola ehrlichii strain MLHE-1, Mono Lake Gammaproteobacter MLHE-1, arsenite-oxidizing bacterium MLHE-1, gamma proteobacterium MLHE-1
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