STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mlg_1328PFAM: phosphoribosyltransferase; KEGG: eba:ebA3304 putative hypoxanthine phosphoribosyltransferase. (198 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
 
 0.968
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.960
Mlg_0578
PFAM: adenylosuccinate synthetase; KEGG: pae:PA4938 adenylosuccinate synthetase.
  
 
 0.945
Mlg_1329
PFAM: purine phosphorylase, family 2; KEGG: noc:Noc_0457 5'-methylthioadenosine phosphorylase.
  
 0.937
Mlg_0611
KEGG: tcx:Tcr_0439 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein.
    
 0.936
Mlg_2444
KEGG: ppu:PP5296 guanylate kinase; PFAM: guanylate kinase; SMART: guanylate kinase/L-type calcium channel region.
     
 0.931
Mlg_1607
PFAM: glutamine amidotransferase class-I; KEGG: mlo:mll8746 hypothetical protein.
  
 
 0.915
Mlg_1637
PFAM: glutamine amidotransferase class-I; KEGG: xfa:XF0560 glutamine amidotransferase.
  
 
 0.915
Mlg_1457
TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mag:amb2392 predicted pyrophosphatase.
    
  0.913
Mlg_2447
TIGRFAM: non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; PFAM: Ham1 family protein; KEGG: sde:Sde_3647 ribosomal protein L33.
  
 
 0.907
Your Current Organism:
Alkalilimnicola ehrlichii
NCBI taxonomy Id: 187272
Other names: A. ehrlichii MLHE-1, Alkalilimnicola ehrlichii MLHE-1, Alkalilimnicola ehrlichii str. MLHE-1, Alkalilimnicola ehrlichii strain MLHE-1, Mono Lake Gammaproteobacter MLHE-1, arsenite-oxidizing bacterium MLHE-1, gamma proteobacterium MLHE-1
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