STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mlg_24624-hydroxy-2-oxovalerate aldolase; PFAM: pyruvate carboxyltransferase; DmpG communication domain protein; KEGG: rme:Rmet_1319 pyruvate carboxyltransferase. (342 aa)    
Predicted Functional Partners:
Mlg_2461
PFAM: Semialdehyde dehydrogenase, NAD - binding; KEGG: bur:Bcep18194_B2960 semialdehyde dehydrogenase, NAD - binding.
 0.999
Mlg_2460
PFAM: Hydratase/decarboxylase; KEGG: bur:Bcep18194_B2961 4-oxalocrotonate decarboxylase.
 
 
 0.994
Mlg_2458
Biphenyl-2,3-diol 1,2-dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: bja:bll5282 biphenyl-2,3-diol 1,2-dioxygenase.
 
   
 0.859
Mlg_2456
2-hydroxymuconate semialdehyde hydrolase; PFAM: alpha/beta hydrolase fold; KEGG: dar:Daro_3786 alpha/beta hydrolase fold.
 
  
 0.818
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 0.813
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
  
  
 0.811
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.806
ilvE
Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.762
Mlg_0543
TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: noc:Noc_2519 acetolactate synthase, small subunit.
  
  
 0.732
ilvD
KEGG: pae:PA0353 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
  
  
 0.672
Your Current Organism:
Alkalilimnicola ehrlichii
NCBI taxonomy Id: 187272
Other names: A. ehrlichii MLHE-1, Alkalilimnicola ehrlichii MLHE-1, Alkalilimnicola ehrlichii str. MLHE-1, Alkalilimnicola ehrlichii strain MLHE-1, Mono Lake Gammaproteobacter MLHE-1, arsenite-oxidizing bacterium MLHE-1, gamma proteobacterium MLHE-1
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