STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_122Mutator MutT related protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, sp:LN:MUTT_STRAM AC:P32091, p()=4.8E-11, pid=25%. (155 aa)    
Predicted Functional Partners:
flpA
Fibrillarin-like pre-rRNA processing protein; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
  
 0.925
MTH_203
ATP-dependent RNA helicase, eIF-4A family; Function Code:10.07 - Metabolism of Macromolecules, Aminoacyl tRNA synthetases and tRNA modification; similar to, gp:GI:g1881268 LN:AB001488, p()=1.2E-83, pid=40%; Belongs to the DEAD box helicase family.
  
 0.925
rrp41
Ribonuclease PH; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails; Belongs to the RNase PH family. Rrp41 subfamily.
    
 0.806
rrp42
Conserved protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site; Belongs to the RNase PH family. Rrp42 subfamily.
    
 0.804
csl4
Conserved protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
   
 0.800
dapF
Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine.
   
 
 0.796
rrp4
Conserved protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
    
 0.764
MTH_1813
Serine protease HtrA; Function Code:10.12 - Metabolism of Macromolecules, Degradation of proteins--peptides--and glycopeptides; similar to, gp:GI:g1652463 LN:D90905, p()=1.9E-48, pid=32%.
  
 
 0.699
rpl40e
Ribosomal protein L40; Function Code:10.04 - Metabolism of Macromolecules, Ribosomal proteins; similar to, sp:LN:RL40_METJA AC:P54058, p()=5.1E-14, pid=55%; Belongs to the eukaryotic ribosomal protein eL40 family.
    
  0.658
MTH_1216
Function Code:9.05 - Metabolism of Cofactors and Vitamins, Pantothenate and CoA biosynthesis; similar to, pir:LN:A64414 AC:A64414, p()=6.1E-66, pid=38%.
  
 
 0.586
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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