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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_1869Activator of (R)-2-hydroxyglutaryl-CoA; Function Code:3.04 - Lipid Metabolism, Sterol biosynthesis; similar to, sp:LN:Y800_METJA AC:Q58210, p()=4.3E-145, pid=66%. (412 aa)    
Predicted Functional Partners:
MTH_1868
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:D64350 AC:D64350, p()=3.4E-40, pid=54%.
  
    0.942
MTH_1866
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:B64362 AC:B64362, p()=2.9E-20, pid=39%.
       0.916
MTH_1865
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:C64476 AC:C64476, p()=5.7E-79, pid=34%; Belongs to the UPF0288 family.
       0.902
MTH_1870
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:B64400 AC:B64400, p()=4.2E-19, pid=31%.
       0.876
MTH_1867
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:E64350 AC:E64350, p()=2.1E-26, pid=38%.
  
    0.824
MTH_1015
Methyl coenzyme M reductase system, component A2; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, gp:GI:g293151, p()=2.7E-278, pid=93%.
 
     0.811
MTH_1871
Nitrogenase iron-molybdenum cofactor biosynthesis protein NifB; Function Code:2.06 - Energy Metabolism, Nitrogen metabolism; similar to, pir:LN:D64436 AC:D64436, p()=1.7E-77, pid=50%.
  
    0.809
MTH_1872
Translation initiation factor eIF-2B, alpha subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
       0.764
MTH_1864
Phosphoribosylformylglycinamidine synthase II related protein; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, pir:LN:H64379 AC:H64379, p()=1.9E-78, pid=45%.
 
     0.735
cfbD
Nitrogenase alpha chain (NifD) related protein; Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes both the six-electron reduction of the tetrahydroporphyrin ring system and the gamma-lactamization of the c- acetamide side chain of Ni-sirohydrochlorin a,c-diamide to yield 15,17(3)-seco-F430-17(3)-acid (seco-F430), the last intermediate in the biosynthesis of the coenzyme F430; Belongs to the NifD/NifK/NifE/N [...]
  
     0.680
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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